Evidence map›Paper›PMID 29092953›Full record

ArticleCancer research2017

TumorMap: Exploring the Molecular Similarities of Cancer Samples in an Interactive Portal.

Yulia Newton, Adam M Novak, Teresa Swatloski, Duncan C McColl, Sahil Chopra, Kiley Graim, Alana S Weinstein, Robert Baertsch, Sofie R Salama, Kyle Ellrott and 5 more

Abstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yulia NewtonDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Adam M NovakDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Teresa SwatloskiDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Duncan C McCollDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Sahil ChopraDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Kiley GraimDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Alana S WeinsteinDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Robert BaertschDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Sofie R SalamaDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Kyle EllrottDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Manu ChopraDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Theodore C GoldsteinDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
David HausslerDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Olena MorozovaDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California.
Joshua M StuartDepartment of Biomolecular Engineering and Bioinformatics, University of California, Santa Cruz, California. jstuart@ucsc.edu.

Funding

Pharmaco Response Signatures and Disease MechanismU54HL127365 · NHLBI · HARVARD MEDICAL SCHOOL · PI SORGER, PETER KARL · 2014 to 2019
$13.1M
Pharmaco Response Signatures and Disease MechanismU54HG006097 · NHGRI · HARVARD MEDICAL SCHOOL · PI MITCHISON, TIMOTHY J, SORGER, PETER KARL · 2010 to 2013
$9.7M
UCSC-Buck Inst. Genome Data Analysis Center for TCGA Research Network (GDAC)U24CA143858 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BENZ, CHRISTOPHER, HAUSSLER, DAVID H · 2009 to 2016
$8.9M
BIGDATA: Mid-Scale DCM: DA: ESCE: Discovering Molecular ProcessesR01CA180778 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STUART, JOSHUA MICHAEL · 2013 to 2017
$3.5M
New Integrative Pathway Analysis Methods to Predict Biomedical OutcomesR01GM109031 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STUART, JOSHUA MICHAEL · 2014 to 2018
$2.9M
UCSC-Buck Specialized Genomic Data Analysis Center for the Genomic Data Analysis NetworkU24CA210990 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STUART, JOSHUA MICHAEL · 2016 to 2020
$2.2M
NCI NIH HHS R01 CA180778NCI NIH HHS U24 CA143858NCI NIH HHS U24 CA210990NHGRI NIH HHS U54 HG006097NIGMS NIH HHS R01 GM109031
6 · The paper itself

Abstract

Vast amounts of molecular data are being collected on tumor samples, which provide unique opportunities for discovering trends within and between cancer subtypes. Such cross-cancer analyses require computational methods that enable intuitive and interactive browsing of thousands of samples based on their molecular similarity. We created a portal called TumorMap to assist in exploration and statistical interrogation of high-dimensional complex "omics" data in an interactive and easily interpretable way. In the TumorMap, samples are arranged on a hexagonal grid based on their similarity to one another in the original genomic space and are rendered with Google's Map technology. While the important feature of this public portal is the ability for the users to build maps from their own data, we pre-built genomic maps from several previously published projects. We demonstrate the utility of this portal by presenting results obtained from The Cancer Genome Atlas project data.

Indexed as

SoftwareChromosome MappingComputational BiologyGene Regulatory NetworksGenetic Predisposition to DiseaseGenome, HumanGenomicsHumansMutationNeoplasmsReproducibility of ResultsUser-Computer Interface

Identifiers

PMID29092953
PMCPMC5751940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.