Evidence map›Paper›PMID 29092949›Full record

ArticleCancer research2017

Integrative Analysis of Histopathological Images and Genomic Data Predicts Clear Cell Renal Cell Carcinoma Prognosis.

Jun Cheng, Jie Zhang, Yatong Han, Xusheng Wang, Xiufen Ye, Yuebo Meng, Anil Parwani, Zhi Han, Qianjin Feng, Kun Huang

Abstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun ChengGuangdong Province Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
Jie ZhangDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio.
Yatong HanCollege of Automation, Harbin Engineering University, Harbin, Heilongjiang, China.
Xusheng WangDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio.
Xiufen YeCollege of Automation, Harbin Engineering University, Harbin, Heilongjiang, China.
Yuebo MengCollege of Information and Control Engineering, Xi'an University of Architecture and Technology, Xi'an, China.
Anil ParwaniDepartment of Pathology, The Ohio State University, Columbus, Ohio.
Zhi HanDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio.
Qianjin FengGuangdong Province Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, China. kunhuang@iu.edu 1271992826@qq.com.
Kun HuangDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio. kunhuang@iu.edu 1271992826@qq.com.

Funding

Informatics Links Between Histological Features and Genetics in CancerU01CA188547 · NCI · OHIO STATE UNIVERSITY · PI HUANG, KUN · 2015 to 2017
$1.2M
NCI NIH HHS U01 CA188547
6 · The paper itself

Abstract

In cancer, both histopathologic images and genomic signatures are used for diagnosis, prognosis, and subtyping. However, combining histopathologic images with genomic data for predicting prognosis, as well as the relationships between them, has rarely been explored. In this study, we present an integrative genomics framework for constructing a prognostic model for clear cell renal cell carcinoma. We used patient data from The Cancer Genome Atlas (

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Renal CellFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenomicsHumansKaplan-Meier EstimateKidneyKidney NeoplasmsMaleMiddle AgedNeoplasm StagingBiomarkers, Tumor

Identifiers

PMID29092949
PMCPMC7262576

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.