Evidence map›Paper›PMID 29092943›Full record

ArticleCancer research2017

The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer.

Debra M Krupke, Dale A Begley, John P Sundberg, Joel E Richardson, Steven B Neuhauser, Carol J Bult

Abstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Murine Models of Obesity-Related Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Web-Based Resources to Investigate Protease Function.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  15. Review
  16. Article
  17. Prostate cancer in omics era.Cancer cell international · 2022
    Article
  18. Early expression of mature αβ TCR in CD4Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Mouse Genome Informatics (MGI): latest news from MGD and GXD.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Debra M KrupkeThe Jackson Laboratory, Bar Harbor, Maine.
Dale A BegleyThe Jackson Laboratory, Bar Harbor, Maine.
John P SundbergThe Jackson Laboratory, Bar Harbor, Maine.
Joel E RichardsonThe Jackson Laboratory, Bar Harbor, Maine.
Steven B NeuhauserThe Jackson Laboratory, Bar Harbor, Maine.
Carol J BultThe Jackson Laboratory, Bar Harbor, Maine. carol.bult@jax.org.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Mouse Models of Human Cancer DatabaseR01CA089713 · NCI · JACKSON LABORATORY · PI BULT, CAROL J · 2002 to 2025
$17.5M
NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA089713
6 · The paper itself

Abstract

Research using laboratory mice has led to fundamental insights into the molecular genetic processes that govern cancer initiation, progression, and treatment response. Although thousands of scientific articles have been published about mouse models of human cancer, collating information and data for a specific model is hampered by the fact that many authors do not adhere to existing annotation standards when describing models. The interpretation of experimental results in mouse models can also be confounded when researchers do not factor in the effect of genetic background on tumor biology. The Mouse Tumor Biology (MTB) database is an expertly curated, comprehensive compendium of mouse models of human cancer. Through the enforcement of nomenclature and related annotation standards, MTB supports aggregation of data about a cancer model from diverse sources and assessment of how genetic background of a mouse strain influences the biological properties of a specific tumor type and model utility.

Indexed as

Databases, GeneticAnimalsDisease Models, AnimalHumansInternetMiceNeoplasms

Identifiers

PMID29092943
PMCPMC5679300

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.