ArticleArchives of disease in childhood. Fetal and neonatal edition2018
One-year outcomes following surgery for necrotising enterocolitis: a UK-wide cohort study.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 59 citations in OpenAlex.
- Surgical Interventions for NEC-An Overview.Children (Basel, Switzerland) · 2026Review
- Epigenetic changes associated with severe necrosis and survival in preterm infants with surgical necrotizing enterocolitis.Pediatric research · 2026Article
- Targeted immune response gene expression profiles linked with necrosis and mortality in preterm infants with surgical necrotizing enterocolitis.World journal of pediatric surgery · 2026Article
- Distinct microbiota profiles in non-survivors in preterm infants with surgical necrotizing enterocolitis: Insights from FFPE intestinal tissue analysis.Journal of neonatal-perinatal medicine · 2025Article
- Initiation of oral intake in neonates with surgical necrotizing enterocolitis: a road map.Pediatric surgery international · 2025Article
- Bedside Utilization of Intestinal Pathology in Preterm Infants with Surgical Necrotizing Enterocolitis.American journal of perinatology · 2025Review
- A predictive model for prognosis in infants with surgical necrotizing enterocolitis.Italian journal of pediatrics · 2025Article
- Necrotizing Enterocolitis-Associated Acute Kidney Injury-Transforming the Paradigm.American journal of perinatology · 2025Review
- Clinical Correlates of Moderate-to-Severe Bronchopulmonary Dysplasia in Preterm Infants following Surgical Necrotizing Enterocolitis.American journal of perinatology · 2024Article
- Defining treatment success in children with surgical conditions.Archives of disease in childhood · 2024Article
- Risk factors for postoperative complications in preterm infants with surgical necrotizing enterocolitis and associated outcomes.Journal of neonatal-perinatal medicine · 2024Article
- Enhancing surgical decision-making in NEC with ResNet18: a deep learning approach to predict the need for surgery through x-ray image analysis.Frontiers in pediatrics · 2024Article
- Clinical correlates of cerebellar injury in preterm infants with surgical necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2024Article
- Clinical Correlates of Cerebellar Injury in Preterm Infants with Surgical Necrotizing Enterocolitis.Research square · 2023Article
- Postoperative Outcomes, and Growth and Brain Injury Outcomes in Spontaneous Intestinal Perforation vs Surgical Necrotizing Enterocolitis in Preterm Infants.Indian pediatrics · 2023Article
- New insights into the pathogenesis of necrotizing enterocolitis and the dawn of potential therapeutics.Seminars in pediatric surgery · 2023Review
- Clinical impact of analgesic-sedative agents and peri-operative clinical status on white matter brain injury in preterm infants following surgical NEC.Journal of neonatal-perinatal medicine · 2023Article
- Clinical determinants and impact of hemorrhagic lesions on intestinal pathology in preterm infants with surgical necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2023Article
- Recent advances in our understanding of NEC diagnosis, prognosis and surgical approach.Frontiers in pediatrics · 2023Review
- Correlation of placental pathology with the postoperative outcomes and white matter injury in preterm infants following necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe objective was to describe outcomes and investigate factors affecting prognosis at 1 year post intervention for infants with surgical necrotising enterocolitis (NEC).
designUsing the British Association of Paediatric Surgeons Congenital Anomalies Surveillance System, we conducted a prospective, multicentre cohort study of every infant reported to require surgical intervention for NEC in the UK and Ireland between 1 March 2013 and 28 February 2014. Association of independent variables with 1-year mortality was investigated using multivariable logistic regression analysis.
settingAll 28 paediatric surgical centres in the UK and Ireland. PATIENTS: Infants were eligible for inclusion if they were diagnosed with NEC and deemed to require surgical intervention, regardless of whether that intervention was delivered. OUTCOMES: Primary outcome was mortality within 1 year of the decision to intervene surgically.
results236 infants were included in the study. 208 (88%) infants had 1-year follow-up. 59 of the 203 infants with known survival status (29%, 95% CI 23% to 36%) died within 1 year of the decision to intervene surgically. Following adjustment, key factors associated with reduced 1-year mortality included older gestational age at birth (adjusted OR (aOR) 0.87, 95% CI 0.78 to 0.96). Being small for gestational age (SGA) (aOR 3.6, 95% CI 1.4 to 9.5) and requiring parenteral nutrition at 28 days post-decision to intervene surgically (aOR 3.5, 95% CI 1.1 to 11.03) were associated with increased 1-year mortality.
conclusionsParents of infants undergoing surgery for NEC should be counselled that there is approximately a 1:3 risk of death in the first post-operative year but that the risk is lower for infants who are of greater gestational age at birth, who are not SGA and who do not require parenteral nutrition at 28 days post-intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.