ArticleThe Journal of biological chemistry2017
Open access · hybridAbstract read
In one paragraph
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 34 citations in OpenAlex.
- Orexin-A Inhibits Lipopolysaccharide-Induced Cell Migration in Cultured Mouse Astrocytes via Activation of Orexin 1 Receptor: Involvement of GABA Signaling.Journal of cellular biochemistry · 2026Article
- The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal CliScience · 2024Article
- Neuronal KActa pharmacologica Sinica · 2024Review
- Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library.Frontiers in molecular neuroscience · 2024Article
- Article
- Serine 937 phosphorylation enhances KCC2 activity and strengthens synaptic inhibition.Scientific reports · 2023Article
- The role ofJournal of pharmaceutical analysis · 2023Review
- Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.Cell reports. Medicine · 2023Article
- Maternal taurine as a modulator of ClFrontiers in cellular neuroscience · 2023Review
- Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia.Kidney international · 2022Article
- Physiological Role of ATPase for GABAInternational journal of molecular sciences · 2022Article
- Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus.Brain : a journal of neurology · 2022Article
- How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders.Frontiers in molecular neuroscience · 2022Review
- NKCC1 and KCC2: Structural insights into phospho-regulation.Frontiers in molecular neuroscience · 2022Review
- The Important Role of Ion Transport System in Cervical Cancer.International journal of molecular sciences · 2021Review
- Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model.Science signaling · 2021Article
- WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal ExcitabilityFrontiers in molecular neuroscience · 2021Article
- Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.PloS one · 2020Article
- The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia.Pflugers Archiv : European journal of physiology · 2019Article
- Ionotropic and metabotropic kainate receptor signalling regulates ClThe Journal of physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Leslie C ConwayFrom the AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts 02111.
Ross A CardarelliFrom the AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts 02111.
Yvonne E MooreDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.
Karen JonesDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park SK10 4TG, United Kingdom.
Lisa J McWilliamsDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
David J BakerDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
Matthew P BurnhamDiscovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park SK10 4TG, United Kingdom.
Roland W BürliNeuroscience, IMED Biotech Unit, AstraZeneca, Cambridge CB21 6GH, United Kingdom, and.
Qi WangFrom the AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts 02111.
Nicholas J BrandonFrom the AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts 02111.
Stephen J MossFrom the AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts 02111, Stephen.Moss@Tufts.edu.
Tarek Z DeebFrom the AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts 02111.
AstraZeneca (United Kingdom) · GBAstraZeneca (United States) · USTufts University · USUniversity College London · GB
Funding
Constructing inhibitory synapsesR01NS051195 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MOSS, STEPHEN J · 2006 to 2014
$3.2MNovel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1MDeficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0MThe role of ubiquitination in regulating GABA(A) receptor functional expressionR01NS056359 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MOSS, STEPHEN J · 2007 to 2010
$1.4MImpaired KCC2 function underlies pharmacoresistant seizuresR21NS080064 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2013 to 2014
$452kNIMH NIH HHS R01 MH097446NINDS NIH HHS R01 NS051195NINDS NIH HHS R01 NS056359NINDS NIH HHS R01 NS087662NINDS NIH HHS R21 NS080064
Abstract
K
Indexed as
AnimalsCell MembraneEmbryo, MammalianEthylmaleimideHumansK Cl- CotransportersMembrane Transport ModulatorsNeuronsPhosphorylationRatsRats, Sprague-DawleyReceptors, GABASymportersEthylmaleimideK Cl- CotransportersMembrane Transport ModulatorsReceptors, GABASymporterschloride transportepilepsyGABA receptorKCC2membrane proteinN-ethylmaleimidephosphorylation
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.