ArticleBMJ open2017
Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effect of Chair-Based Exercise on Physical Function in Older Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Pooled it
- Epigenome-wide Analysis Identifies Genes and Pathways Linked to Neurobehavioral Variation in Preterm Infants.Scientific reports · 2019Trial
- Biological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.Aging clinical and experimental research · 2026Article
- The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study.Clinical epigenetics · 2026Article
- Biological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE-T Cohort.Journal of cachexia, sarcopenia and muscle · 2025Article
- Epigenetic Aging and Musculoskeletal Outcomes in a Cohort of Women Living With HIV.The Journal of infectious diseases · 2024Article
- Associations of Epigenetic Age Acceleration With CVD Risks Across the Lifespan: The Bogalusa Heart Study.JACC. Basic to translational science · 2024Article
- Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA): health assessment protocol, participant profile and patterns of participation.BMC public health · 2023Article
- Article
- Pace of aging, family environment and cognitive skills in children and adolescents.SSM - population health · 2022Article
- A set of common buccal CpGs that predict epigenetic age and associate with lifespan-regulating genes.iScience · 2022Article
- The Association Between Epigenetic Clocks and Physical Functioning in Older Women: A 3-Year Follow-up.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study.Epigenetics · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- The epigenetic aging, obesity, and lifestyle.Frontiers in cell and developmental biology · 2022Review
- Life course socioeconomic position and DNA methylation age acceleration in mid-life.Journal of epidemiology and community health · 2021Article
- Invited Commentary: Epigenetic Clocks and Obesity-Towards the Next Frontier Using Integrative Approaches and Early-Life Models.American journal of epidemiology · 2021Article
- Combined healthy lifestyle score and risk of epigenetic aging: a discordant monozygotic twin study.Aging · 2021Article
- Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity.Clinical epigenetics · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesOur aim was to investigate the association of epigenetic age and physical capability in later life. Having a higher epigenetic than chronological age (known as age acceleration (AA)) has been found to be associated with an increased rate of mortality. Similarly, physical capability has been proposed as a marker of ageing due to its consistent associations with mortality.
settingThe MRC National Survey of Health and Development (NSHD) cohort study.
participantsWe used data from 790 women from the NSHD who had DNA methylation data available.
designEpigenetic age was calculated using buccal cell (n=790) and matched blood tissue (n=152) from 790 female NSHD participants. We investigated the association of AA at age 53 with changes in physical capability in women from ages 53 to 60-64. Regression models of change in each measure of physical capability on AA were conducted. Secondary analysis focused on the relationship between AA and smoking, alcohol, body mass index (BMI) and socioeconomic position. OUTCOME MEASURES: Three objective measures of physical capability were used: grip strength, standing balance time and chair rise speed.
resultsEpigenetic age was lower than chronological age (mean 53.4) for both blood (50.3) and buccal cells (42.8). AA from blood was associated with a greater decrease in grip strength from ages 53 to 60-64 (0.42 kg decrease per year of AA, 95% CI 0.03, 0.82 kg; p=0.03, n=152), but no associations were observed with standing balance time or chair rise speed. Current smoking and lower BMI were associated with lower epigenetic age from buccal cells.
conclusionsWe found evidence that AA in blood is associated with a greater decrease in grip strength in British females aged between 53 and 60-64, but no association with standing balance time or chair rise speed was found.
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