ArticleJournal of the American Heart Association2017
Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01110538 (The Massachusetts General Hospital Optical Coherence Tomography Registry), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Massachusetts General Hospital Optical Coherence Tomography Registry
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High-intensity statin therapy yields better outcomes in acute coronary syndrome patients: a meta-analysis involving 26,497 patients.Lipids in health and disease · 2020Pooled it
- Establishment of a Biaxial Testing System for Characterization of Right Ventricle Viscoelasticity Under Physiological Loadings.Cardiovascular engineering and technology · 2024Article
- Exercise Intensity and Coronary Plaque Composition: Is Harder, Better, Faster, Stronger?Journal of the American Heart Association · 2022Article
- Potent platelet inhibition with peri-procedural tirofiban may attenuate progression of atherosclerosis in patients with acute coronary syndromes.Journal of thrombosis and thrombolysis · 2022Article
- Predictors for Rapid Progression of Coronary Calcification: An Optical Coherence Tomography Study.Journal of the American Heart Association · 2021Article
- Optical Coherence Tomography Predictors for a Favorable Vascular Response to Statin Therapy.Journal of the American Heart Association · 2021Observational
- Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study.International journal of cardiology. Heart & vasculature · 2019Article
- Can OCT change the therapeutic strategy in ACS due to plaque erosion?Indian heart journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin-cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. METHODS AND
resultsA total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical coherence tomography imaging (median interval, 6.3 months) were included. Thin-cap area (fibrous cap thickness, <200 μm) was measured using a novel 3-dimensional computer-aided algorithm. Overall, the thin-cap area significantly decreased from baseline (median, 2.852 mm
conclusionsChronic kidney disease is an independent predictor for the lack of a favorable vascular response to statin therapy, whereas acute coronary syndrome is an independent predictor for favorable vascular response to statin therapy. These findings should be further warranted in future prospective studies. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01110538.
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