Evidence map›Paper›PMID 29092646›Full record

ArticleDrug delivery2017

Synergistic dual-modified liposome improves targeting and therapeutic efficacy of bone metastasis from breast cancer.

Xianzhu Ke, Wen Lin, Xiaokang Li, Hailiang Wang, Xin Xiao, Zheng Guo

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xianzhu Kea Department of Orthopedics , Xijing Hospital, Fourth Military Medical University , Xi'an , China.
Wen Linc Department of Clinical Laboratory , Huangshi Love & Health Hospital of Hubei Province , Huangshi , China.
Xiaokang Lia Department of Orthopedics , Xijing Hospital, Fourth Military Medical University , Xi'an , China.
Hailiang Wanga Department of Orthopedics , Xijing Hospital, Fourth Military Medical University , Xi'an , China.
Xin Xiaoa Department of Orthopedics , Xijing Hospital, Fourth Military Medical University , Xi'an , China.
Zheng Guoa Department of Orthopedics , Xijing Hospital, Fourth Military Medical University , Xi'an , China.
Xijing Hospital · CNAir Force Medical University · CNHuangshi Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer frequently metastasizes to bone, where it leads to poor clinical prognosis. Due to the peculiarity of the bone microstructure, the uptake of drugs often happens at non-targeted sites, which produces a similar cytotoxicity in both cancerous and healthy cells. In this study, a rational strategy was implemented to take advantage of a combination of both an octapeptide with eight repeating sequences of aspartate (Asp

Indexed as

AnimalsBone NeoplasmsBreast NeoplasmsCell Line, TumorCell SurvivalDoxorubicinDrug Delivery SystemsFemaleFolic AcidHumansLiposomesMaleimidesMiceMice, NudePhosphatidylethanolaminesPolyethylene Glycols1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)DoxorubicinFolic Acidliposomal doxorubicinLiposomesmaleimideMaleimidesPhosphatidylethanolaminesPolyethylene GlycolsAsp8 peptideBone metastasisbone targetingdual-modified liposomesfolate

Identifiers

PMID29092646
PMCPMC8241154
OpenAlexW2765299242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.