Evidence map›Paper›PMID 29091764›Full record

ArticleCell reports2017

A CREB-MPP7-AMOT Regulatory Axis Controls Muscle Stem Cell Expansion and Self-Renewal Competence.

Lydia Li, Chen-Ming Fan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harbor perspectives in biology · 2026
    Article
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  10. Roles of THEM4 in the Akt pathway: a double-edged sword.Journal of Zhejiang University. Science. B · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lydia LiDepartment of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA; Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA.
Chen-Ming FanDepartment of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA; Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA. Electronic address: fan@carnegiescience.edu.
Department of Embryology · US

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Muscle Stem Cell LineageR01AR060042 · NIAMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI FAN, CHEN-MING · 2010 to 2019
$3.5M
NIAMS NIH HHS R01 AR060042NIGMS NIH HHS T32 GM007231
6 · The paper itself

Abstract

Skeletal muscle regeneration requires resident muscle stem cells, termed satellite cells (SCs). SCs are largely quiescent during homeostasis yet become activated upon injury to supply myonuclei and self-renewed SCs. Molecular mechanisms underlying the competence of SCs to proliferate and self-renew in response to injury remain unclear. Here, we show that CREB activity establishes proliferative potential during SC quiescence. SCs with inhibited CREB activity remain quiescent and positioned in their niche, but upon injury, they cannot enter or maintain a proliferative state for expansion and self-renewal. We demonstrate mechanistically that Mpp7 is a CREB target and its functional mediator. MPP7 loss affects the level and sub-cellular localization of AMOT and YAP1 in quiescent SCs. Furthermore, MPP7 and AMOT are required for YAP1 nuclear accumulation, and the three are individually required for a proliferative state in myoblasts. We propose that the CREB-MPP7-AMOT-YAP1 axis establishes the competence of quiescent SCs to expand and self-renew, thereby preserving stem cell function.

Indexed as

Adaptor Proteins, Signal TransducingAngiomotinsAnimalsCell Cycle ProteinsCell ProliferationCells, CulturedCell Self RenewalCyclic AMP Response Element-Binding ProteinHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsMembrane ProteinsMiceMicrofilament ProteinsMicroscopy, FluorescenceMyoblastsAdaptor Proteins, Signal TransducingAmot protein, mouseAngiomotinsCell Cycle ProteinsCyclic AMP Response Element-Binding ProteinIntercellular Signaling Peptides and ProteinsMembrane ProteinsMicrofilament ProteinsMyoD1 myogenic differentiation proteinMyoD ProteinPax7 protein, mousePAX7 Transcription FactorPhosphoproteinsRNA, Small InterferingYap1 protein, mouseYAP-Signaling Proteins

Identifiers

PMID29091764
PMCPMC5710848
OpenAlexW2766396805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.