ArticlePloS one2017
The fine-scale genetic structure and evolution of the Japanese population.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Genetic Structures ofAnimals : an open access journal from MDPI · 2026Article
- Intricate interactions between fine-scale genetic structure, lifestyle, and dietary habits in the Japanese population.Communications biology · 2025Article
- Fine-scale population structure of JapaneseMicrobial genomics · 2025Article
- Genetic analysis of a Yayoi individual from the Doigahama site provides insights into the origins of immigrants to the Japanese Archipelago.Journal of human genetics · 2025Article
- Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals.Clocks & sleep · 2022Article
- Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians.Molecular biology and evolution · 2021Article
- Fine-Scale Genetic Structure and Demographic History in the Miyako Islands of the Ryukyu Archipelago.Molecular biology and evolution · 2021Article
- Changes in the fine-scale genetic structure of Finland through the 20th century.PLoS genetics · 2021Article
- Population genomics of East Asian ethnic groups.Hereditas · 2020Review
- Genome-Wide Natural Selection Signatures Are Linked to Genetic Risk of Modern Phenotypes in the Japanese Population.Molecular biology and evolution · 2020Article
- The Origin and Composition of Korean Ethnicity Analyzed by Ancient and Present-Day Genome Sequences.Genome biology and evolution · 2020Article
- Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction.Nature communications · 2020Article
- Japan considered from the hypothesis of farmer/language spread.Evolutionary human sciences · 2020Review
- Genetics of Obesity in East Asians.Frontiers in genetics · 2020Review
- Patterns of genetic differentiation and the footprints of historical migrations in the Iberian Peninsula.Nature communications · 2019Article
- Article
- Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project.BMC genomics · 2018Article
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17 authors.
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Abstract
The contemporary Japanese populations largely consist of three genetically distinct groups-Hondo, Ryukyu and Ainu. By principal-component analysis, while the three groups can be clearly separated, the Hondo people, comprising 99% of the Japanese, form one almost indistinguishable cluster. To understand fine-scale genetic structure, we applied powerful haplotype-based statistical methods to genome-wide single nucleotide polymorphism data from 1600 Japanese individuals, sampled from eight distinct regions in Japan. We then combined the Japanese data with 26 other Asian populations data to analyze the shared ancestry and genetic differentiation. We found that the Japanese could be separated into nine genetic clusters in our dataset, showing a marked concordance with geography; and that major components of ancestry profile of Japanese were from the Korean and Han Chinese clusters. We also detected and dated admixture in the Japanese. While genetic differentiation between Ryukyu and Hondo was suggested to be caused in part by positive selection, genetic differentiation among the Hondo clusters appeared to result principally from genetic drift. Notably, in Asians, we found the possibility that positive selection accentuated genetic differentiation among distant populations but attenuated genetic differentiation among close populations. These findings are significant for studies of human evolution and medical genetics.
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