Evidence map›Paper›PMID 29091543›Full record

ArticleBioengineered2018

In silico design of a novel chimeric shigella IpaB fused to C terminal of clostridium perfringens enterotoxin as a vaccine candidate.

Sina Arabshahi, Bahar Nayeri Fasaei, Abdollah Derakhshandeh, Aytak Novinrooz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A NovelmSphere · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sina Arabshahia Department of Pathobiology , School of Veterinary Medicine, Shiraz University , Shiraz , Iran.
Bahar Nayeri Fasaeib Department of Microbiology and Immunology, Faculty of Veterinary Medicine , University of Tehran , Tehran , Iran.
Abdollah Derakhshandeha Department of Pathobiology , School of Veterinary Medicine, Shiraz University , Shiraz , Iran.
Aytak Novinrooza Department of Pathobiology , School of Veterinary Medicine, Shiraz University , Shiraz , Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to design a novel chimeric protein in silico to serve as a serotype-independent vaccine candidate against Shigella. The chimera contains amino acid residues 240-460 of Shigella invasion plasmid antigen B (IpaB) and the C-terminus of Clostridium perfringens enterotoxin (C-CPE). Amino acid sequences of 537 peptide linkers were obtained from two protein linker databases. 3D structures of IpaB-CPE

Indexed as

Amino Acid SequenceBacterial ProteinsBinding SitesB-LymphocytesClostridium perfringensDatabases, ProteinDysentery, BacillaryEnterotoxinsEpitopes, B-LymphocyteEscherichia coliGenetic EngineeringHumansModels, MolecularPlasmidsProtein BindingProtein Conformation, alpha-HelicalBacterial Proteinsenterotoxin, ClostridiumEnterotoxinsEpitopes, B-LymphocyteipaB protein, ShigellaRecombinant Fusion ProteinsShigella VaccinesChimeric proteinCPEIpaBShigellaVaccine candidate

Identifiers

PMID29091543
PMCPMC5972921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.