ArticleDento maxillo facial radiology2018
Evidence of genotoxicity and cytotoxicity of X-rays in the oral mucosa epithelium of adults subjected to cone beam CT.
Article in Dento maxillo facial radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05532514 (EFFECT OF LIMITED VOLUME CONE BEAM COMPUTED TOMOGRAPHY ON MICRONUCLEI CELLS COUNT OF BUCCAL MUCOSA), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of limited volume cone beam computed tomography on micronuclei cells count of buccal mucosa
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Does cone-beam computed tomography examination increase the micronuclei frequency in the oral mucosa exfoliated cells? A systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Can exposure to panoramic radiographs induce genotoxic effects on the oral epithelium? A systematic review with meta-analysis.Dento maxillo facial radiology · 2022Pooled it
- Review
- Risk Assessment of Genotoxicity and Cytotoxicity of Cone Beam Computed Tomography Exposure: A Systematic Review.Acta medica Philippina · 2026Article
- Genotoxic and cytotoxic effects of cone beam computed tomography on exfoliated epithelial cells in different age groups.BMC oral health · 2025Article
- Article
- Genotoxic and Cytotoxic Effects of Cone Beam Computed Tomography and Multidetector Computed Tomography on Exfoliated Buccal Epithelial Cells.Iranian journal of medical sciences · 2023Article
- Genotoxicity and cytotoxicity effects of x-rays on the oral mucosa epithelium at different fields of view: A cone beam computed tomography technique.Caspian journal of internal medicine · 2023Article
- Genotoxicity and cytotoxicity of cone beam computed tomography in children.BMC oral health · 2021Article
- Radiobiological risks following dentomaxillofacial imaging: should we be concerned?Dento maxillo facial radiology · 2021Review
- Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra.Scientific reports · 2021Article
- Evidence of genotoxicity and cytotoxicity of X-rays in the oral mucosa epithelium of adults subjected to cone beam computed tomography.Dento maxillo facial radiology · 2019Article
- Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations.Dento maxillo facial radiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess cytological evidence of genotoxicity and cytotoxicity of X-rays in oral exfoliated cells of adults subjected to partial and total cone beam CT (CBCT) (stitching module) by means of micronuclei frequency, associated with counting of degenerative nuclear alterations (pyknosis, karyolysis, karyorrhexis, buds and broken eggs), besides comparing the partial and total CBCT (stitching module) in search of possible differences in the nature and/or intensity of the effects.
methods29 adults who were referred to total or partial CBCT were selected. All CBCT were performed with a Carestream CS 9000 3D scanner (Carestream Health Inc., Rochester, NY). Material collection was done immediately before CBCT and 10 days later, by scraping the left and right cheek mucosa with a plastic spatula. Statistical analysis was performed using the Wilcoxon test (paired data), at a significance level of 5%.
resultsThe statistically significant difference was noted in the frequency of micronucleated cells for both partial and total acquisition (p = 0.008 and p < 0.001, respectively). Regarding to cytotoxicity, there was a statistically significant difference for both partial and total acquisition (p < 0.001 and p < 0.001, respectively).
conclusionsThe partial and total CBCT seems to offer risks of inducing genetic damage. In addition both forms of CBCT acquisition have promoted the induction of cytotoxic nuclear alterations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.