ArticleDevelopmental psychobiology2018
Developmental social isolation affects adult behavior, social interaction, and dopamine metabolite levels in zebrafish.
Article in Developmental psychobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Anxiolytic-like effects of acute serotonin-releasing agents in zebrafish models of anxiety: experimental study and systematic review.Acta neuropsychiatrica · 2024Pooled it
- Social isolation is associated with microRNA expression changes in the visual system of poison frog tadpoles.bioRxiv : the preprint server for biology · 2026Article
- Social isolation, rather than kinship, influences association behavior in toad tadpoles (Bufo formosus).Animal cognition · 2026Article
- Fish welfare in a changing world: New developments and current challenges.Journal of fish biology · 2026Review
- Experience-dependent modulation of collective behavior in larval zebrafish.Nature communications · 2026Article
- Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder.Journal of neurochemistry · 2026Review
- Parental social environment has transgenerational effects on zebrafish (Danio rerio) growth.Scientific reports · 2025Article
- Paradise fish (Macropodus opercularis) as a complementary translational model for emotional and cognitive function.Communications biology · 2025Article
- Zebrafish metabolomics: a comprehensive approach to understanding health and disease.Functional & integrative genomics · 2025Review
- Early social isolation disrupts adult personality expression in group-living mites.The Journal of animal ecology · 2025Article
- Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood.iScience · 2024Article
- Zebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool.International journal of molecular sciences · 2024Review
- Chronic social isolation affects feeding behavior of juvenile zebrafish (Danio rerio).PloS one · 2024Article
- Article
- High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice.Biology · 2022Article
- Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2.Biology open · 2022Article
- Article
- Article
- Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio).Scientific reports · 2022Article
- The effect of fish density and tank size on the behavior of adult zebrafish: A systematic analysis.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The zebrafish is a social vertebrate and an excellent translational model for a variety of human disorders. Abnormal social behavior is a hallmark of several human brain disorders. Social behavioral problems can arise as a result of adverse early social environment. Little is known about the effects of early social isolation in adult zebrafish. We compared zebrafish that were isolated for either short (7 days) or long duration (180 days) to socially housed zebrafish, testing their behavior across ontogenesis (ages 10, 30, 60, 90, 120, 180 days), and shoal cohesion and whole-brain monoamines and their metabolites in adulthood. Long social isolation increased locomotion and decreased shoal cohesion and anxiety in the open-field in adult. Additionally, both short and long social isolation reduced dopamine metabolite levels in response to social stimuli. Thus, early social isolation has lasting effects in zebrafish, and may be employed to generate zebrafish models of human neuropsychiatric conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.