ArticleThe Journal of antimicrobial chemotherapy2017
Dental staining after doxycycline use in children.
Article in The Journal of antimicrobial chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.German medical science : GMS e-journal · 2025Guideline
- Dental safety of short-term doxycycline use in children under 8 years: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Incidence and influencing factors of tooth discoloration in children using doxycycline: a meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Human monocytotropic ehrlichiosis-A systematic review and analysis of the literature.PLoS neglected tropical diseases · 2024Pooled it
- Therapeutic efficacy of pharmacist-integrated clinic in evidence-based treatment for pediatric mycoplasma pneumoniae pneumonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Trial
- Mycoplasma pneumoniae infections in the Post-COVID era: recent advances from pathogenesis to clinical management.Infection · 2026Review
- Risk of Permanent Dental Staining Following Exposure to Newer-Generation Tetracycline Derivatives in Children: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2026Review
- High infant mortality, eschar absence, and universal CNS involvement in scrub typhus-associated HLH: a case series and narrative synthesis of 91 pediatric cases.Tropical medicine and health · 2026Article
- Article
- Two Cases of Q Fever in Pregnancy, including Management of the Newborn, Australia.Emerging infectious diseases · 2026Review
- Clinical characteristics of community acquired pneumonia due toLe infezioni in medicina · 2026Article
- Peripheral facial palsy in children: Serum Borrelia antibodies may reduce the need for lumbar puncture.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- [Efficacy of prolonged azithromycin versus switching to doxycycline in the treatment of macrolide-unresponsiveZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- A Review of Hidradenitis Suppurativa in Special Populations: Considerations in Children, Pregnant and Breastfeeding Women, and the Elderly.Dermatology and therapy · 2024Review
- Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.World journal of pediatrics : WJP · 2024Review
- Alternatives to β-Lactams as Agents for the Management of Dentoalveolar Abscess.Current topics in medicinal chemistry · 2024Review
- Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma.Cell death & disease · 2023Article
- Cutaneous Manifestations of Lyme Borreliosis in Children-A Case Series and Review.Life (Basel, Switzerland) · 2022Article
- Risk of Dental Discoloration and Enamel Dysplasia in Children Exposed to Tetracycline and Its Derivatives.Yonsei medical journal · 2022Article
- Development and Reversal of Discolouration in Roots Filled with Ledermix or Doxymix Pastes Stored in the Dark for Three Months then Daylight for Twenty Four Months.European endodontic journal · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The use of doxycycline has been avoided before 8 years of age due to known dental staining caused by tetracyclines, although doxycycline differs from classical tetracyclines in many ways. Doxycycline is still an important antimicrobial agent, but its dental safety is not well studied. Objectives: To examine the state of permanent teeth after doxycycline exposure in children <8 years of age. Methods: Details of doxycycline treatment were collected from medical records. After the eruption of permanent teeth the dental status was examined by an experienced paediatric dentist for detection of dental staining and enamel hypoplasia. The resulting dental photographs were evaluated by a second independent experienced paediatric dentist. Results: The mean age of 38 study subjects at the time of doxycycline treatment was 4.7 years (range 0.6-7.9 years, SD 2.3). The doxycycline dose was 10 mg/kg/day (varying from 8 to 10 mg/kg/day) for the first 2-3 days and 5 mg/kg/day (varying from 2.5 to 10 mg/kg/day) thereafter. The mean length of the treatment was 12.5 days (SD 6.0) and ranged from 2 to 28 days. Tetracycline-like staining or enamel hypoplasia of developing teeth was detected in none of the subjects. Conclusions: Doxycycline treatment of small children does not seem to induce permanent tooth staining.
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Registered trials
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