ArticleMemorias do Instituto Oswaldo Cruz2017
Lack of association between rrl and erm(41) mutations and clarithromycin resistance in Mycobacterium abscessus complex.
Article in Memorias do Instituto Oswaldo Cruz, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Subspecies Identification and Characterization of Drug Resistance and Virulence Factors in Clinical Strains ofInfectious disease reports · 2026Article
- The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Review
- Optimizing macrolide resistance detection forMicrobiology spectrum · 2025Article
- Evaluation of the In Vitro Activity of Bedaquiline, Delamanid, and Clofazimine AgainstPathogens (Basel, Switzerland) · 2025Article
- Subspecies distribution and drug-resistance characteristics ofMicrobiology spectrum · 2025Article
- The geneAntimicrobial agents and chemotherapy · 2025Article
- Analysis of Phenotypic and Genotypic Susceptibility to Clarithromycin and Amikacin ofMicroorganisms · 2023Article
- Article
- Review
- Molecular epidemiology and phylogenomic analysis ofMicrobial genomics · 2021Article
- Whole-Genome Sequences of Mycobacterium abscessus subsp.Microbiology resource announcements · 2021Article
- An Update in Antimicrobial Therapies and Infection Prevention in Pediatric Lung Transplant Recipients.Paediatric drugs · 2018Review
- Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMycobacterium abscessus complex (MABC) includes species with high resistance rates among mycobacterial pathogens. In fact, MABC infections may not respond to clarithromycin treatment, which has historically been very effective against MABC infection. Molecular markers have been proposed to detect both acquired (rrl polymorphisms) and inducible (erm(41) polymorphisms) clarithromycin resistance in MABC isolates.
objectivesThis study aimed to evaluate the susceptibility profile and molecular markers of clarithromycin resistance in MABC.
methodsThe clarithromycin susceptibility profile was determined by broth microdilution with reads on days 3, 5, 7 and 14. Mutations in the rrl and erm(41) genes were evaluated by polymerase chain reaction (PCR) using specific primers, followed by sequencing.
findingsA total of 14 M. abscessus subsp. abscessus isolates and 28 M. abscessus subsp. massiliense isolates were evaluated, and clarithromycin resistance was observed in all isolates for up to three days of incubation. None of the 42 isolates exhibited a point mutation in the rrl gene, while all the isolates had a T28 polymorphism in the erm(41) gene. Moreover, all 28 M. abscessus subsp. massiliense isolates had a deletion in the erm(41) gene. MAIN
conclusionsWhile all the MABC isolates exhibited acquired clarithromycin resistance, no isolates exhibited a point mutation in the rrl gene in this study. The M. abscessus subsp. massiliense isolates demonstrated clarithromycin resistance, which is an uncommon phenotype. The molecular data for the rrl and erm(41) genes were not consistent with the phenotypic test results of clarithromycin susceptibility, indicating a lack of correlation between molecular clarithromycin resistance markers for both acquired and inducible resistance.
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