Evidence map›Paper›PMID 29091032›Full record

ArticleeLife2017

Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators.

Jutta Nesper, Isabelle Hug, Setsu Kato, Chee-Seng Hee, Judith Maria Habazettl, Pablo Manfredi, Stephan Grzesiek, Tilman Schirmer, Thierry Emonet, Urs Jenal

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 75 citations in OpenAlex.

  1. Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulateProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. ComFB, a widespread family of c-di-NMP receptor proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. ComFB, a new widespread family of c-di-NMP receptor proteins.bioRxiv : the preprint server for biology · 2024
    Article
  5. Review
  6. A flagellar accessory protein links chemotaxis to surface sensing.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. The ecological roles of bacterial chemotaxis.Nature reviews. Microbiology · 2022
    Review
  11. Controlling Biofilm Development Through Cyclic di-GMP Signaling.Advances in experimental medicine and biology · 2022
    Review
  12. Review
  13. TheMicroorganisms · 2021
    Article
  14. Article
  15. Bioengineering ofToxins · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jutta Nesper *Focal Area of Infection Biology, Biozentrum of the University of Basel, Basel, Switzerland.
Isabelle Hug *Focal Area of Infection Biology, Biozentrum of the University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-4524-9569
Setsu Kato *Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.
Chee-Seng Hee *Focal Area of Structural Biology and Biophysics, Biozentrum of the University of Basel, Basel, Switzerland.
Judith Maria HabazettlFocal Area of Structural Biology and Biophysics, Biozentrum of the University of Basel, Basel, Switzerland.
Pablo ManfrediFocal Area of Infection Biology, Biozentrum of the University of Basel, Basel, Switzerland.
Stephan GrzesiekFocal Area of Structural Biology and Biophysics, Biozentrum of the University of Basel, Basel, Switzerland.
Tilman SchirmerFocal Area of Structural Biology and Biophysics, Biozentrum of the University of Basel, Basel, Switzerland.
Thierry EmonetDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID http://orcid.org/0000-0002-6746-6564
Urs JenalFocal Area of Infection Biology, Biozentrum of the University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1637-3376
University of Basel · CHYale University · US

Funding

The contribution of phenotypic variability to chemotactic performanceR01GM106189 · NIGMS · YALE UNIVERSITY · PI EMONET, THIERRY · 2013 to 2022
$2.6M
NIGMS NIH HHS R01 GM106189
6 · The paper itself

Abstract

The flagellar motor is a sophisticated rotary machine facilitating locomotion and signal transduction. Owing to its important role in bacterial behavior, its assembly and activity are tightly regulated. For example, chemotaxis relies on a sensory pathway coupling chemical information to rotational bias of the motor through phosphorylation of the motor switch protein CheY. Using a chemical proteomics approach, we identified a novel family of CheY-like (Cle) proteins in

Indexed as

Bacterial AdhesionChemotaxisGene Expression Regulation, BacterialBacterial ProteinsCaulobacter crescentusCyclic GMPFlagellaProtein BindingProteomeBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPProteomeattachmentCaulobacter crescentusc-di-GMPchemotaxisflagelluminfectious diseasemicrobiologymotility

Identifiers

PMID29091032
PMCPMC5677366
OpenAlexW2765751461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.