Evidence map›Paper›PMID 29090684›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum.

Laura E Dichtel, Elizabeth A Lawson, Melanie Schorr, Erinne Meenaghan, Margaret Lederfine Paskal, Kamryn T Eddy, Graziano Pinna, Marianela Nelson, Ann M Rasmusson, Anne Klibanski and 1 more

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Sex Steroids in COVID-19 Patients with Hypertension: An Exploratory Study.International journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Gut feelings: the microbiota-gut-brain axis on steroids.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura E DichtelNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Elizabeth A LawsonNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Melanie SchorrNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Erinne MeenaghanNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Margaret Lederfine PaskalNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Graziano PinnaThe Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Marianela NelsonThe Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Ann M RasmussonNational Center for PTSD, Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA, USA.
Anne KlibanskiNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Karen K MillerNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5M
Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
IGF-I AND BONE LOSS IN WOMEN WITH ANOREXIA NERVOSAR01DK052625 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KLIBANSKI, ANNE · 1997 to 2015
$6.9M
Hormonal Factors in the Treatment of Anorexia NervosaR01MH083657 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI KLIBANSKI, ANNE · 2010 to 2014
$2.1M
Growth Hormone and Cardiovascular DiseaseK24HL092902 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KAREN K · 2010 to 2019
$1.6M
The Growth Hormone and Insulin-like Growth Factor-1 Axis in Nonalcoholic Fatty Liver Disease and Nonalcoholic SteatohepatitisK23DK113220 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DICHTEL, LAURA ELISABETH · 2017 to 2021
$1.1M
NCATS NIH HHS UL1 TR001102NHLBI NIH HHS K24 HL092902NICHD NIH HHS K12 HD051959NIDDK NIH HHS K23 DK113220NIDDK NIH HHS R01 DK052625NIDDK NIH HHS T32 DK007028NIMH NIH HHS R01 MH083657
6 · The paper itself

Abstract

3α-5α-Tetrahydroprogesterone, a progesterone metabolite also known as allopregnanolone, and 5α-androstane-3α,17β-diol, a testosterone metabolite also known as 3α-androstanediol, are neuroactive steroids and positive GABA

Indexed as

AdultAffective SymptomsAndrostane-3,17-diolAnorexia NervosaAnxietyBody Mass IndexCross-Sectional StudiesDepressionFemaleHumansOverweightPregnanoloneProgesteronePsychiatric Status Rating ScalesSeverity of Illness IndexTestosteroneAndrostane-3,17-diolPregnanoloneProgesteroneTestosterone

Identifiers

PMID29090684
PMCPMC5916351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.