Evidence map›Paper›PMID 29090678›Full record

SynthesisEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2017

Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence.

Fernando J García López, María Ruiz-Tovar, Javier Almazán-Isla, Enrique Alcalde-Cabero, Miguel Calero, Jesús de Pedro-Cuesta

Open access · diamondAbstract readSystematic Review
In one paragraph

Synthesis in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fernando J García LópezNational Epidemiology Centre, Carlos III Institute of Health, Madrid, Spain.
María Ruiz-TovarNational Epidemiology Centre, Carlos III Institute of Health, Madrid, Spain.
Javier Almazán-IslaNational Epidemiology Centre, Carlos III Institute of Health, Madrid, Spain.
Enrique Alcalde-CaberoNational Epidemiology Centre, Carlos III Institute of Health, Madrid, Spain.
Miguel CaleroCenter for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Jesús de Pedro-CuestaNational Epidemiology Centre, Carlos III Institute of Health, Madrid, Spain.
Biomedical Research Networking Center on Neurodegenerative Diseases · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSporadic Creutzfeldt-Jakob disease (sCJD) is potentially transmissible to humans.

objectiveThis study aimed to summarise and rate the quality of the evidence of the association between surgery and sCJD. DESIGN AND

methodsFirstly, we conducted systematic reviews and meta-analyses of case-control studies with major surgical procedures as exposures under study. To assess quality of evidence, we used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Secondly, we conducted a systematic review of sCJD case reports after sharing neurosurgical instruments.

resultsThirteen case-control studies met the inclusion criteria for the systematic review of case-control studies. sCJD was positively associated with heart surgery, heart and vascular surgery and eye surgery, negatively associated with tonsillectomy and appendectomy, and not associated with neurosurgery or unspecified major surgery. The overall quality of evidence was rated as very low. A single case-control study with a low risk of bias found a strong association between surgery conducted more than 20 years before disease onset and sCJD. Seven cases were described as potentially transmitted by reused neurosurgical instruments.

conclusionThe association between surgery and sCJD remains uncertain. Measures currently recommended for preventing sCJD transmission should be strongly maintained. Future studies should focus on the potential association between sCJD and surgery undergone a long time previously.

Indexed as

Surgical InstrumentsCreutzfeldt-Jakob SyndromeFemaleHumansMaleMiddle AgedNeurosurgical ProceduresPrion DiseasesSurgical Procedures, OperativeCase-control studiesCJDCreutzfeldt-Jakob diseaseNeurosurgerySurgerySystematic reviewTransmissible spongiform encephalopathies

Identifiers

PMID29090678
PMCPMC5718390
OpenAlexW2766832030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.