Evidence map›Paper›PMID 29090626›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences.

Christopher T Smith, Jennifer L Crawford, Linh C Dang, Kendra L Seaman, M Danica San Juan, Aishwarya Vijay, Daniel T Katz, David Matuskey, Ronald L Cowan, Evan D Morris and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The role of dopamine decline, astrocyte reactivity and cerebral small-vessel disease in cognitive aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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  20. Geometric influences on the regional organization of the mammalian brain.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Christopher T Smith1 Department of Psychology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-8212-7886
Jennifer L Crawford2 Department of Psychology, Yale University, New Haven, CT, USA.
Linh C Dang1 Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Kendra L Seaman2 Department of Psychology, Yale University, New Haven, CT, USA.
M Danica San Juan1 Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Aishwarya Vijay4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Daniel T Katz1 Department of Psychology, Vanderbilt University, Nashville, TN, USA.
David Matuskey4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Ronald L Cowan1 Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Evan D Morris4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
David H Zald1 Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Gregory R Samanez-Larkin2 Department of Psychology, Yale University, New Haven, CT, USA.
Vanderbilt University · USDuke University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged AdultsR01AG043458 · NIA · VANDERBILT UNIVERSITY · PI SAMANEZ LARKIN, GREGORY R, ZALD, DAVID HAROLD · 2014 to 2018
$2.3M
Dopaminergic Modulation of Subjective Valuation across AdulthoodR01AG044838 · NIA · VANDERBILT UNIVERSITY · PI ZALD, DAVID HAROLD · 2012 to 2014
$1.6M
Neuromodulation of Motivated Cognition and Decision Making Across AdulthoodR00AG042596 · NIA · YALE UNIVERSITY · PI SAMANEZ LARKIN, GREGORY R · 2014 to 2016
$730k
Radiofluorination Equipment for PET Imaging ResearchS10OD019963 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2016 to 2016
$291k
Linking Temporal Differences in d-Amphetamine Subjective Effects to DRD2 and DATF32DA041157 · NIDA · VANDERBILT UNIVERSITY · PI SMITH, CHRISTOPHER THOMAS · 2016 to 2018
$174k
Dopamine function in reward-driven decision makingF32DA036979 · NIDA · VANDERBILT UNIVERSITY · PI DANG, LINH CAT · 2015 to 2017
$173k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001863NIA NIH HHS R00 AG042596NIA NIH HHS R01 AG043458NIA NIH HHS R01 AG044838NIDA NIH HHS F32 DA036979NIDA NIH HHS F32 DA041157
6 · The paper itself

Abstract

The relatively modest spatial resolution of positron emission tomography (PET) increases the likelihood of partial volume effects such that binding potential (BP

Indexed as

AgingAdultAgedBrainDopamineFemaleGray MatterHumansMaleMiddle AgedPositron-Emission TomographyProtein BindingReceptors, Dopamine D2DopamineReceptors, Dopamine D2AgingD2 receptorsdopaminepartial volume correctionpositron emission tomography imaging

Identifiers

PMID29090626
PMCPMC6498753
OpenAlexW2766550758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.