Evidence map›Paper›PMID 29090487›Full record

ArticleMagnetic resonance in medicine2018

Influence of parameter accuracy on pharmacokinetic analysis of hyperpolarized pyruvate.

Chang-Yu Sun, Christopher M Walker, Keith A Michel, Aradhana M Venkatesan, Stephen Y Lai, James A Bankson

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  7. New Horizons in HyperpolarizedMolecular imaging and biology · 2024
    Article
  8. Hyperpolarized [2-NeuroImage · 2023
    Article
  9. Article
  10. The effect of transmit BMedical physics · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chang-Yu SunDepartment of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-8102-7130
Christopher M WalkerDepartment of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-6381-8737
Keith A MichelDepartment of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-4330-6881
Aradhana M VenkatesanDepartment of Diagnostic Radiology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Stephen Y LaiDepartment of Head & Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-8301-7286
James A BanksonDepartment of Imaging Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-8574-154X
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Multi-Site Development & Evaluation of a Quantitative 3D Hyperpolarized C-13 MRI Clinical Prostate Cancer ExamR01CA211150 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BANKSON, JAMES A · 2017 to 2021
$3.2M
Optimizing Radiosensitization in Anaplastic Thyroid Cancer with Metabolic ImagingR21CA178450 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2014 to 2015
$383k
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA211150NCI NIH HHS R21 CA178450
6 · The paper itself

Abstract

purposeTo explore the effects of noise and error on kinetic analyses of tumor metabolism using hyperpolarized [1-

methodsNumerical simulations were performed to systematically investigate the effects of noise, the number of unknowns, and error in kinetic parameter estimates on kinetic analysis of the apparent rate of chemical conversion from hyperpolarized pyruvate to lactate (k

resultsThe reproducibility of k

conclusionsThe accuracy and precision of k

Indexed as

NeoplasmsPyruvic AcidCarbon IsotopesComputer SimulationHumansImage Processing, Computer-AssistedKineticsMagnetic Resonance ImagingModels, BiologicalCarbon IsotopesPyruvic Aciddynamic nuclear polarizationhyperpolarized pyruvatekinetic modelingtumor metabolism

Identifiers

PMID29090487
PMCPMC5843516
OpenAlexW2766869714

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.