ArticleMagnetic resonance in medicine2018
Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed.
- Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3-deficient muscular dystrophy.Animal models and experimental medicine · 2026Article
- The effect of microstructural variations in tendon and ligament on diffusion tensor MRI.bioRxiv : the preprint server for biology · 2026Article
- Smartphone video-based knee extension moments during chair rise relate to MRI measures of muscle function.medRxiv : the preprint server for health sciences · 2026Article
- Quantitative evaluation of cervical muscles in patients with degenerative cervical myelopathy using diffusion tensor imaging metrics.Bone & joint research · 2026Article
- Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study.BMC medical imaging · 2026Article
- Histology-informed microstructural diffusion simulations for MRI cancer characterisation-the Histo-μSim framework.Communications biology · 2025Article
- Relationships between diffusion tensor parameters and measures of skeletal muscle fiber size and strength after anterior cruciate ligament injury.Magnetic resonance imaging · 2025Article
- Diffusion Tensor Imaging of Rat Rotator Cuff Muscle With Histopathological Correlation: An Exploratory Study.NMR in biomedicine · 2025Article
- Quantifying structural properties of forearm flexor muscles in individuals with hemiparetic cerebral palsy using diffusion tensor imaging.Physiological reports · 2025Article
- Assessment of muscle fiber types transformation in rats with discogenic low back pain using diffusion tensor image of paraspinal muscles.BMC medical imaging · 2025Article
- Texture analysis of T1- and T2-weighted images identifies myofiber atrophy and grip strength decline in streptozotocin-induced type 1 diabetic sarcopenia rats.Journal of orthopaedic surgery and research · 2025Article
- Characterization of anthracycline-induced cardiotoxicity by diffusion tensor magnetic resonance imaging.Basic research in cardiology · 2025Article
- From Voxels to Physiology: A Review of Diffusion Magnetic Resonance Imaging Applications in Skeletal Muscle.Journal of magnetic resonance imaging : JMRI · 2025Review
- Multiparametric MRI Assessment of Morpho-Functional Muscle Changes Following a 6-Month FES-Cycling Training Program: Pilot Study in People With a Complete Spinal Cord Injury.JMIR rehabilitation and assistive technologies · 2025Article
- Daily feeding frequency impacts muscle characteristics and fat deposition in finishing pigs associated with alterations in microbiota composition and bile acid profile.Frontiers in microbiology · 2025Article
- Optimal Setup and Parameters of Diffusion-Weighted Magnetic Resonance Imaging for Translational Evaluation of a Tumor Progression Model for Soft Tissue Sarcomas.Advances in radiation oncology · 2025Article
- Investigating skeletal muscle micro-trauma with time-dependent diffusion and the random permeable barrier model.Scientific reports · 2024Article
- Pre- and post-skeletal muscle biopsy quantitative magnetic resonance imaging reveals correlations with histopathological findings.European journal of neurology · 2024Article
- Accelerated, Physics-Inspired Inference of Skeletal Muscle Microstructure From Diffusion-Weighted MRI.IEEE transactions on medical imaging · 2024Article
- The Prediction of Radiation-Induced Trismus by the Apparent Diffusion Coefficient Values of Masseter Muscles before Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinomas.Diagnostics (Basel, Switzerland) · 2024Article
5 more citing papers are in PubMed but not listed here.
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Abstract
purposeTo establish a series of relationships defining how muscle microstructure and diffusion tensor imaging (DTI) are related.
methodsThe relationship among key microstructural features of skeletal muscle (fiber size, fibrosis, edema, and permeability) and the diffusion tensor were systematically simulated over physiologically relevant dimensions individually, and in combination, using a numerical simulation application. Stepwise multiple regression was used to identify which microstructural features of muscle significantly predict the diffusion tensor using single-echo and multi-echo DTI pulse sequences. Simulations were also performed in models with histology-informed geometry to investigate the relationship between fiber size and the diffusion tensor in models with real muscle geometry.
resultsFiber size is the strongest predictor of λ2, λ3, mean diffusivity, and fractional anisotropy in skeletal muscle, accounting for approximately 40% of the variance in the diffusion model when calculated with single-echo DTI. This increased to approximately 70% when diffusion measures were calculated from the short T
conclusionsAs the normal fiber size of a human muscle fiber is 40 to 60 μm, this suggests that DTI is a sensitive tool to monitor muscle atrophy, but may be limited in measurements of muscle with larger fibers. Magn Reson Med 80:317-329, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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