ArticleThe Journal of physiology2018
Enhanced skeletal muscle regrowth and remodelling in massaged and contralateral non-massaged hindlimb.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Guideline
- Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy.Function (Oxford, England) · 2026Trial
- Cross-education attenuates muscle weakness and facilitates strength recovery after orthopedic immobilization in females: A pilot study.Physiological reports · 2025Trial
- Visual monitoring in real-time improves consistency of 3D IASTM force applied to humans.Chiropractic & manual therapies · 2026Observational
- Integrin-β1/FAK signaling is involved in electrical stimulation to prevent disuse muscular atrophy induced by tail suspension in mice.BMC musculoskeletal disorders · 2026Article
- Mechanisms and Efficacy of Massage Therapy for Post-Exercise Muscle Repair: A Narrative Review.Muscles (Basel, Switzerland) · 2026Review
- Technologies to investigate the mechanisms of force-based manipulations: a narrative methods review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Critical-Size Muscle Defect Regeneration Using an Injectable Cell-Laden Nanofibrous Matrix: An Ex Vivo Mouse Hindlimb Organ Culture Study.International journal of molecular sciences · 2025Article
- Donepezil treatment, alone or combined with exercise, enhances skeletal muscle function in healthy and advanced aging disease mouse models.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Trajectories of Recovery after ACutE and cRitical illness (TRACER): a prospective observational study protocol.BMJ open · 2025Article
- Review
- Soft tissue manipulation enhances recovery of muscle mass in a disuse model of sarcopenia.Journal of osteopathic medicine · 2025Article
- Unilateral electrical stimulation of mice induces transcriptional response in stimulated leg with limited effect on non-stimulated contralateral leg.Experimental physiology · 2025Article
- Rheumatoid hand massage therapy to mitigate sarcopenia and improve patients' quality of life: a hypothesis.Rheumatology international · 2025Review
- Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction.Experimental physiology · 2025Review
- Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging.GeroScience · 2025Article
- Responses of skeletal muscle to mechanical stimuli in female rats following and during muscle disuse atrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?Experimental physiology · 2025Review
- Measuring HSD17β13 protein turnover in mouse liver with DBioanalysis · 2025Article
- Age-induced changes in skeletal muscle mitochondrial DNA synthesis, quantity, and quality in genetically unique rats.GeroScience · 2025Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
key pointsMuscle fibre cross sectional area is enhanced with massage in the form of cyclic compressive loading during regrowth after atrophy. Massage enhances protein synthesis of the myofibrillar and cytosolic, but not the mitochondrial fraction, in muscle during regrowth. Focal adhesion kinase activation and satellite cell number are elevated in muscles undergoing massage during regrowth. Muscle fibre cross sectional area and protein synthesis of the myofibrillar fraction, but not DNA synthesis, are elevated in muscle of the contralateral non-massaged limb. Massage in the form of cyclic compressive loading is a potential anabolic intervention during muscle regrowth after atrophy. ABSTRACT: Massage, in the form of cyclic compressive loading (CCL), is associated with multiple health benefits, but its potential anabolic effect on atrophied muscle has not been investigated. We hypothesized that the mechanical activity associated with CCL induces an anabolic effect in skeletal muscle undergoing regrowth after a period of atrophy. Fischer-Brown Norway rats at 10 months of age were hindlimb unloaded for a period of 2 weeks. The rats were then allowed reambulation with CCL applied at a 4.5 N load at 0.5 Hz frequency for 30 min every other day for four bouts during a regrowth period of 8 days. Muscle fibre cross sectional area was enhanced by 18% with massage during regrowth compared to reloading alone, and this was accompanied by elevated myofibrillar and cytosolic protein as well as DNA synthesis. Focal adhesion kinase phosphorylation indicated that CCL increased mechanical stimulation, while a higher number of Pax7
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.