Evidence map›Paper›PMID 29090431›Full record

ArticleJournal of endocrinological investigation2018

Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients.

A D Genazzani, K Shefer, D Della Casa, A Prati, A Napolitano, A Manzo, G Despini, T Simoncini

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06418347 (Effect of Alpha-Lipoic Acid Supplementation on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females Treated With Letrozole), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06418347 phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Alpha-Lipoic Acid Supplementation on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females Treated With Letrozole

TypeinterventionalSponsorAin Shams UniversityRan2024 to 2025Enrolled150ConditionsPolycystic Ovary Syndrome, Infertility, FemaleArmsAlpha lipoic acid, Letrozole
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  10. Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention.Revista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia · 2023
    Review
  11. Review
  12. Review
  13. Dietary supplements for polycystic ovary syndrome.Journal of preventive medicine and hygiene · 2022
    Review
  14. Article
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  16. Article
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  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

A D GenazzaniDepartment of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy. algen@unimo.it.
K SheferDepartment of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy.
D Della CasaDepartment of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy.
A PratiDepartment of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy.
A NapolitanoDepartment of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy.
A ManzoDepartment of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy.
G DespiniDepartment of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy.
T SimonciniDepartment of Obstetrics and Gynecology, University of Pisa, Pisa, Italy.
University of Modena and Reggio Emilia · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the efficacy of alpha-lipoic acid (ALA) administration on hormonal and metabolic parameters of obese PCOS patients.

methodsA group of 32 obese PCOS patients were selected after informed consent. 20 patients referred to have first grade relatives with diabetes type I or II. Hormonal and metabolic parameters as well as OGTT were evaluated before and after 12 weeks of ALA integrative administration (400 mg per os every day).

resultsALA administration significantly decreased insulin, glucose, BMI and HOMA index. Hyperinsulinemia and insulin response to OGTT decreased both as maximal response (Δmax) and as AUC. PCOS with diabetes relatives showed the decrease also of triglyceride and GOT. Interestingly in all PCOS no changes occurred on all hormonal parameters involved in reproduction such as LH, FSH, and androstenedione.

conclusionsALA integrative administration at a low dosage as 400 mg daily improved the metabolic impairment of all PCOS patients especially in those PCOS with familiar diabetes who have a higher grade of risk of NAFLD and predisposition to diabetes.

Indexed as

Insulin ResistanceAdultAntioxidantsBody Mass IndexDiabetes MellitusFemaleFollow-Up StudiesHumansObesityPolycystic Ovary SyndromePrognosisThioctic AcidYoung AdultAntioxidantsThioctic AcidAlpha-lipoic-acidFamiliar diabetesHyperinsulinemiaInsulin resistancePCOS

Identifiers

PMID29090431
OpenAlexW2767077622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.