Evidence map›Paper›PMID 29090350›Full record

ArticlePediatric cardiology2018

Longer Ischemic Time is Associated with Increased Ventricular Stiffness as Measured by Pressure-Volume Loop Analysis in Pediatric Heart Transplant Recipients.

Luke W Schroeder, Shahryar M Chowdhury, Ali L Burnette, Minoo N Kavarana, G Hamilton Baker, Andrew J Savage, Andrew M Atz, Ryan J Butts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Clinical Applications of Pressure-Volume Assessment in Congenital Heart Disease.Journal of the Society for Cardiovascular Angiography & Interventions
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luke W SchroederDivision of Cardiology, Department of Pediatrics, Medical University of South Carolina, 165 Ashley Ave, MSC 915, Charleston, SC, 29425, USA. schroedl@musc.edu.ORCID http://orcid.org/0000-0001-8072-0021
Shahryar M ChowdhuryDivision of Cardiology, Department of Pediatrics, Medical University of South Carolina, 165 Ashley Ave, MSC 915, Charleston, SC, 29425, USA.
Ali L BurnetteDivision of Cardiology, Department of Pediatrics, Medical University of South Carolina, 165 Ashley Ave, MSC 915, Charleston, SC, 29425, USA.
Minoo N KavaranaDivision of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA.
G Hamilton BakerDivision of Cardiology, Department of Pediatrics, Medical University of South Carolina, 165 Ashley Ave, MSC 915, Charleston, SC, 29425, USA.
Andrew J SavageDivision of Cardiology, Department of Pediatrics, Medical University of South Carolina, 165 Ashley Ave, MSC 915, Charleston, SC, 29425, USA.
Andrew M AtzDivision of Cardiology, Department of Pediatrics, Medical University of South Carolina, 165 Ashley Ave, MSC 915, Charleston, SC, 29425, USA.
Ryan J ButtsDivision of Cardiology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.

Funding

Research Training in Pediatric CardiologyT32HL007710 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRAHAM, ERIC M. · 1994 to 2014
$3.6M
NHLBI NIH HHS L40 HL120025NHLBI NIH HHS T32 HL007710
6 · The paper itself

Abstract

backgroundThe purpose of this study was to investigate the associations between clinical factors and cardiac function as measured by pressure-volume loops (PVLs) in a pediatric heart transplant cohort.

methodsPatients (age < 20 years) who underwent heart transplantation presenting for a clinically indicated catheterization were enrolled. PVLs were recorded using microconductance catheters (CD Leycom

resultsA total of 18 patients were enrolled. Median age was 8.7 years (IQR 5-14 years). There were ten males and eight females. Six patients had a history of rejection and ten had positive donor-specific antibodies. There was no transplant coronary artery disease. Median BNP was 100 pg/mL (IQR 46-140). Time from transplant to PVL obtained during catheterization procedure was 4.1 years (IQR 1.7-7.8 year). No single clinical characteristic was statistically significant when correlated with PVL data. However, longer ischemic time was associated with worse Beta (r = 0.49, p = 0.05).

conclusionsOur study found that longer ischemic times are associated with increased left ventricular stiffness. No other single clinical variable is associated with cardiac dysfunction as determined by PVL analysis.

Indexed as

AdolescentBiomarkersCardiac CatheterizationChildChild, PreschoolFemaleHeart TransplantationHeart VentriclesHumansMaleMyocardial IschemiaNatriuretic Peptide, BrainPrimary Graft DysfunctionRisk FactorsTime FactorsVentricular DysfunctionBiomarkersNatriuretic Peptide, BrainGraft dysfunctionHeart transplantIschemic timePediatrics

Identifiers

PMID29090350
PMCPMC5799027

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.