Evidence map›Paper›PMID 29090275›Full record

ArticleBiochemistry and biophysics reports2017

Activation of TPA-response element present in human Lemur Tyrosine Kinase 2 (

Isha Dey, Neil A Bradbury

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Lemur Tyrosine Kinases and Prostate Cancer: A Literature Review.International journal of molecular sciences · 2021
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Isha DeyDepartment of Physiology and Biophysics, Chicago Medical School, North Chicago IL, USA.
Neil A BradburyDepartment of Physiology and Biophysics, Chicago Medical School, North Chicago IL, USA.
Rosalind Franklin University of Medicine and Science · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory elements present in the promoter of a gene drive the expression of the gene in response to various stimuli. Lemur Tyrosine Kinase 2 (LMTK2) is a membrane-anchored Serine/Threonine kinase involved in endosomal protein trafficking and androgen signaling amongst other processes. Previous studies have shown this protein to be of therapeutic importance in cystic fibrosis and prostate cancer. However, nothing is known about the endogenous expression of this protein and its regulation. In this study, we analyzed the gene encoding human LMTK2, to look for possible regulatory elements that could affect its expression. Interestingly, the human

Indexed as

4α-TPA, 4α-phorbol 12, 13-didecanoateACD, Actinomycin DAP-1, Activator Protein – 1AP-1 complexChx, CycloheximideGM-CSF, Granulocyte Macrophage Colony Stimulating FactorLMTK2LMTK2, Lemur Tyrosine Kinase 2Phorbol esterPKC activationPKC, Protein Kinase CPromoterSEAP, Secretory Alkaline PhosphataseTPA, Phorbol 12-myristate 13-acetateTPA-responsive elementTRE, TPA-response element

Identifiers

PMID29090275
PMCPMC5645172
OpenAlexW2757718269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.