ArticleReports of biochemistry & molecular biology2017
Paraoxonase 1 Activity, Lipid Profile, and Atherogenic Indexes Status in Coronary Heart Disease.
Article in Reports of biochemistry & molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03646019 (Serum Oxidative Status as a Potential Predictor of Coronary Artery Disease.), which is not on this map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum Oxidative Status as a Potential Predictor of Coronary Artery Disease.
Who cites it
11 citing papers in PubMed.
- Paraoxonase-1 Is a Pivotal Regulator Responsible for Suppressing Allergic Airway Inflammation Through Adipose Stem Cell-Derived Extracellular Vesicles.International journal of molecular sciences · 2024Article
- Paraoxonases at the Heart of Neurological Disorders.International journal of molecular sciences · 2023Review
- miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations.PloS one · 2023Article
- Rebaudioside A Enhances LDL Cholesterol Uptake in HepG2 Cells via Suppression ofReports of biochemistry & molecular biology · 2021Article
- Pineapple consumption reduced cardiac oxidative stress and inflammation in high cholesterol diet-fed rats.Nutrition & metabolism · 2021Article
- Effects ofBioImpacts : BI · 2020Article
- Relationship between Paraoxonase-1 and Arylesterase Enzyme Activities and SYNTAX I and II Scores in Patients with ST-Elevation Myocardial Infarction.The journal of Tehran Heart Center · 2019Article
- Oxidative Stress Status and Liver Markers in Coronary Heart Disease.Reports of biochemistry & molecular biology · 2019Article
- Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.Nature communications · 2018Article
- Effects of Plasma Lipids and Statins on Cognitive Function.Chinese medical journal · 2018Review
- Differential effect of metformin and/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: Concepts and clinical practice.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDyslipidemia is considered an independent risk factor for coronary heart disease (CHD). In the present study, we examined lipid profiles and paraoxonase 1 (PON1) activity and atherogenic indexes status and the relationship of PON1 activity by high-density lipoprotein (HDL) and atherogenic indexes in CHD patients and healthy people.
methodsThe aim of the study was to compare PON1, lipid profiles, and atherogenic indexes in CHD patients and healthy people as controls. This study enrolled 50 CHD patients and 50 matched healthy controls. Serum activities of PON1 and levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), and atherogenic indexes were analyzed. Data were analyzed by unpaired Student's t tests. Coefficients of correlation were calculated using Pearson's correlation analysis.
resultsLevels of TG, TC, LDL, VLDL, FBG, and atherogenic indexes, atherogenic coefficients, and cardiac risk ratios were significantly greater in CHD patients than in controls. Paraoxonase 1 activity and HDL-C levels were significantly less in CHD patients than in controls. Also, PON1 activity correlated positively with HDLC and negatively with atherogenic coefficient, and cardiac risk ratios 1 and 2 in CHD patients.
conclusionThis study showed that CHD is associated with high lipid levels and atherogenic indexes, and low PON1 activity and HDL-C concentrations. Coronary heart disease is a pernicious disease requiring prolonged medical management and hypolipidemic drugs.
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Identifiers
29090223PMC5643455What OpenQuestion holds
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