Evidence map›Paper›PMID 29090120›Full record

ArticleToxicology reports2017

Magnesium stearate, a widely-used food additive, exhibits a lack of

Cheryl A Hobbs, Kazuhiko Saigo, Mihoko Koyanagi, Shim-Mo Hayashi

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 38 citations in OpenAlex.

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  5. COVID-19 Therapeutics: Use, Mechanism of Action, and Toxicity (Xenobiotics).Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023
    Review
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  12. Oral and TopicalEvidence-based complementary and alternative medicine : eCAM · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Cheryl A HobbsToxicology Program, Integrated Laboratory Systems, Inc., PO Box 13501, Research Triangle Park, NC 27709, USA.
Kazuhiko SaigoDrug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura-cho, Kagoshima-City, Kagoshima 891-1394, Japan.
Mihoko KoyanagiGlobal Scientific and Regulatory Affairs, San-Ei Gen F.F.I., Inc., 1-1-11 Sanwa-cho, Toyonaka, Osaka 561-8588, Japan.
Shim-Mo HayashiGlobal Scientific and Regulatory Affairs, San-Ei Gen F.F.I., Inc., 1-1-11 Sanwa-cho, Toyonaka, Osaka 561-8588, Japan.
San-Ei Gen F.F.I (Japan) · JPShin Nippon Biomedical Laboratories (Japan) · JPTriangle · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium stearate is widely used in the production of dietary supplement and pharmaceutical tablets, capsules and powders as well as many food products, including a variety of confectionery, spices and baking ingredients. Although considered to have a safe toxicity profile, there is no available information regarding its potential to induce genetic toxicity. To aid safety assessment efforts, magnesium sulfate was evaluated in a battery of tests including a bacterial reverse mutation assay, an

Indexed as

2AA, 2-aminoanthracene9AA, 9-aminoacridine hydrochloride monohydrateADI, acceptable daily intakeAF-2, 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamideDietary supplementDMSO, dimethyl sulfoxideDNA damageEFSA, European Food Safety AuthorityENNG, N-ethyl-N'-nitro-N-nitrosoguanidineFAO, Food and Agriculture Organization of the United NationsFDA, U.S. Food and Drug AdministrationFood additiveGenotoxicityGLP, Good Laboratory PracticeJECFA, Joint FAO/WHO Expert Committee on Food AdditivesJoint FAO/WHO Expert Committee on Food Additives (JECFA)Magnesium stearateMMC, mitomycin CMN, micronucleus or micronucleiMN-PCE, micronucleated polychromatic erythrocyte(s)OECD, Organization for Economic Cooperation and DevelopmentPCE, polychromatic erythrocyte(s)WHO, World Health Organization

Identifiers

PMID29090120
PMCPMC5655391
OpenAlexW2766499375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.