Evidence map›Paper›PMID 29089997›Full record

ArticleNeural regeneration research2017

Blocking beta 2-adrenergic receptor inhibits dendrite ramification in a mouse model of Alzheimer's disease.

Qin Wu, Jin-Xia Sun, Xiang-He Song, Jing Wang, Cun-Quan Xiong, Fei-Xiang Teng, Cui-Xiang Gao

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  9. Microarray Analysis of Differential Gene Expression in Alzheimer's Disease Identifies Potential Biomarkers with Diagnostic Value.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qin WuJiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
Jin-Xia SunCollege of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, China.
Xiang-He SongCollege of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, China.
Jing WangCollege of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, China.
Cun-Quan XiongCollege of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, China.
Fei-Xiang TengCollege of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, China.
Cui-Xiang GaoCollege of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, China.ORCID 0000-0003-3857-1215
Jiangsu Vocational College of Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendrite ramification affects synaptic strength and plays a crucial role in memory. Previous studies revealed a correlation between beta 2-adrenergic receptor dysfunction and Alzheimer's disease (AD), although the mechanism involved is still poorly understood. The current study investigated the potential effect of the selective β

Indexed as

Alzheimer's diseaseamyloid precursor proteinamyloid-βbeta-2 adrenergic receptorcognitive functiondendrite ramificationICI 118551nerve regenerationneural regenerationneurodegenerationsynapsin 1synaptophysinα-secretase

Identifiers

PMID29089997
PMCPMC5649472
OpenAlexW2759705819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.