Evidence map›Paper›PMID 29089993›Full record

ArticleNeural regeneration research2017

Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion.

Zhi-Yuan Li, Yan-Ting Yang, Jue Hong, Dan Zhang, Xiao-Fei Huang, Li-Jie Wu, Huan-Gan Wu, Zheng Shi, Jie Liu, Yi Zhu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zhi-Yuan LiShanghai University of Traditional Chinese Medicine, Shanghai, China.
Yan-Ting YangShanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID 0000-0003-1388-4047
Jue HongShanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
Dan ZhangShanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiao-Fei HuangShanghai University of Traditional Chinese Medicine, Shanghai, China.
Li-Jie WuShanghai University of Traditional Chinese Medicine, Shanghai, China.
Huan-Gan WuShanghai University of Traditional Chinese Medicine, Shanghai, China.
Zheng ShiShanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
Jie LiuShanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
Yi ZhuShanghai Research Institute of Acupuncture and Meridian, Shanghai, China.
Xiao-Peng MaShanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID 0000-0002-0582-3562
Shanghai University of Traditional Chinese Medicine · CNShanghai Research Center for Acupuncture and Meridians · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic mechanism is still unclear. Moreover, extracellular signal-regulated kinase, substance P, and neurokinin-1 are involved in formation of central hyperalgesia. Thus, we postulated that the analgesic effect of herb-partitioned moxibustion may be associated with these factors. Accordingly, in this study, we established an inflammatory bowel disease visceral pain model in rat by enema with a mixed solution of 5% trinitrobenzenesulfonic acid and 50% ethanol. Bilateral

Indexed as

analgesic effectdorsal root ganglionextracellular signal-regulated kinaseherb-partitioned moxibustioninflammatory bowel diseasenerve regenerationneural regenerationneurokinin-1Qihai (CV6)substance PTianshu (ST25)visceral pain

Identifiers

PMID29089993
PMCPMC5649468
OpenAlexW2760660812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.