Evidence map›Paper›PMID 29089946›Full record

ArticleFrontiers in immunology2017

Association between Systemic Lupus Erythematosus and Periodontitis: A Systematic Review and Meta-analysis.

Zoe Rutter-Locher, Toby O Smith, Ian Giles, Nidhi Sofat

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04046172 (Treatment of Periodontal Disease in Systemic Lupus Erytematosus), which is not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04046172 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Treatment of Periodontal Disease in Systemic Lupus Erytematosus: A Pilot Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversity College, LondonRan2021 to 2023Enrolled200ConditionsSystemic Lupus Erythematosus, PeriodontitisArmssupra/sub gingival root surface debridement, supra-gingival scaling and polishing
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Exploring oral health care needs of Canadians with rheumatic diseases: a qualitative study.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026
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  6. Review
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  8. Review
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  15. Therapeutic effects of peptide P140 in a mouse periodontitis model.Cellular and molecular life sciences : CMLS · 2022
    Article
  16. Observational
  17. Antibodies toJournal of clinical medicine · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zoe Rutter-LocherMusculoskeletal Research Group, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
Toby O SmithFaculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom.
Ian GilesCenter for Rheumatology Research, Rayne Institute, University College London, London, United Kingdom.
Nidhi SofatMusculoskeletal Research Group, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
St George's, University of London · GBUniversity College London · GBUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease, the etiology of which remains only partially characterized. Strong evidence implicates chronic infections in the development and chronicity of autoimmune conditions. Recently, an association has been demonstrated between periodontitis and rheumatoid arthritis. Such observations have led to the investigation of the possible role of periodontitis and oral dysbiosis in other systemic inflammatory conditions, including SLE. The aim of this study was to examine whether there is an association between SLE and periodontitis.

methodsMEDLINE

resultsEight case-control studies were included, with 487 SLE cases and a total of 1,383 participants. On meta-analysis of four studies, risk of periodontitis in SLE cases compared to controls was significantly greater with a risk ratio of 1.76 (95% CI 1.29-2.41,

conclusionOur study found a statistically significant increased risk of periodontitis in patients with SLE compared to controls. This finding suggests a possible association between these two conditions. Larger longitudinal studies are needed to confirm this possible association.

Indexed as

autoimmune and inflammatory diseasesmeta-analysismicroorganismsperiodontal diseaseperiodontitissystemic lupus erythematosus

Identifiers

PMID29089946
PMCPMC5650969
OpenAlexW2765531887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.