ArticleFrontiers in neurology2017
Altered Insular and Occipital Responses to Simulated Vertical Self-Motion in Patients with Persistent Postural-Perceptual Dizziness.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07374640 (Virtual Reality and Biofeedback for Adolescents With Chronic Dizziness), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Virtual Reality and Biofeedback for Adolescents With Chronic Dizziness
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Clinical characteristics of visual motion hypersensitivity: a systematic review.Experimental brain research · 2023Pooled it
- Neuroimaging studies in persistent postural-perceptual dizziness and related disease: a systematic review.Journal of neurology · 2022Pooled it
- Brain activation in persistent postural-perceptual dizziness (PPPD) in response to various visual motion stimuli eliciting abnormal egomotion perception.NeuroImage. Clinical · 2026Article
- Early Ocular Response to Visual Motion in Patients With Persistent Postural-Perceptual Dizziness.Annals of the New York Academy of Sciences · 2026Article
- [Gait characteristics in patients with persistent postural-perceptual dizziness].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Evolution of Research on Persistent Postural-Perceptual Dizziness: A Bibliometric and Visualization Analysis from 1994 to 2025.Audiology research · 2026Review
- Vestibular and visual influence on postural stability and egomotion perception in persistent postural-perceptual dizziness (PPPD).Journal of neurology · 2026Article
- Visual-Vestibular Modification of Egomotion Perception in Patients With Persistent Postural-Perceptual Dizziness in Supine and Standing Positions.Brain and behavior · 2026Article
- Vestibular-Visual Reweighting in Persistent Postural-Perceptual Dizziness: A Multilevel Resting-State fMRI Study.Neural plasticity · 2026Article
- Persistent postural-perceptual dizziness versus vestibular migraine: A narrative review.Headache · 2026Review
- Altered functional connectivity of nucleus accumbens in patients with persistent postural-perceptual dizziness: a resting-state functional magnetic resonance imaging study.Frontiers in psychiatry · 2026Article
- Chronic dizziness: neuro-sensitization and psycho-sensitization.Frontiers in integrative neuroscience · 2026Review
- Attentional dysfunction in persistent postural-perceptual dizziness: a narrative review of mechanistic evidence.Frontiers in neurology · 2026Review
- Neurotransmitter regulatory networks in persistent postural-perceptual dizziness: potential mechanisms and therapeutic implications.Frontiers in neurology · 2026Review
- Spatial Orientation Impairment in Patients With Bilateral Vestibulopathy and Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Article
- The Role of Vestibular Physical Therapy in Managing Persistent Postural-Perceptual Dizziness: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Functional brain activity in persistent postural-perceptual dizziness (PPPD) during galvanic vestibular stimulation reveals sensitization in the multisensory vestibular cortical network.Scientific reports · 2025Article
- Diagnostics and Group Therapy in Patients with Persistent Postural-Perceptual Dizziness and Anxiety Disorder: Biomarkers and Neurofunctional Correlates of Underlying Treatment Effects.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Research Progress on the Potential Pathogenesis of Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundPersistent postural-perceptual dizziness (PPPD) is a common functional vestibular disorder characterized by persistent symptoms of non-vertiginous dizziness and unsteadiness that are exacerbated by upright posture, self-motion, and exposure to complex or moving visual stimuli. Recent physiologic and neuroimaging data suggest that greater reliance on visual cues for postural control (as opposed to vestibular cues-a phenomenon termed visual dependence) and dysfunction in central visuo-vestibular networks may be important pathophysiologic mechanisms underlying PPPD. Dysfunctions are thought to involve insular regions that encode recognition of the visual effects of motion in the gravitational field.
methodsWe tested for altered activity in vestibular and visual cortices during self-motion simulation obtained
resultsHCs showed increased activity in the anterior bank of the central insular sulcus during vertical relative to horizontal motion, which was not seen in patients with PPPD. However, for the same comparison, dizziness handicap correlated positively with activity in the visual cortex (V1, V2, and V3) in patients with PPPD.
conclusionWe provide novel insight into the pathophysiologic mechanisms underlying PPPD, including functional alterations in brain processes that affect balance control and reweighting of space-motion inputs to favor visual cues. For patients with PPPD, difficulties using visual data to discern the effects of gravity on self-motion may adversely affect balance control, particularly for individuals who simultaneously rely too heavily on visual stimuli. In addition, increased activity in the visual cortex, which correlated with severity of dizziness handicap, may be a neural correlate of visual dependence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.