ArticleFrontiers in pharmacology2017
Inactivation of the Prelimbic Cortex Impairs the Context-Induced Reinstatement of Ethanol Seeking.
Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.Current topics in behavioral neurosciences · 2025Review
- Dopamine and Norepinephrine Tissue Levels in the Developing Limbic Brain Are Impacted by the HumanInternational journal of molecular sciences · 2024Article
- Chemogenetic inhibition of the ventral hippocampus but not its direct projection to the prelimbic cortex attenuates context-specific operant responding.Frontiers in behavioral neuroscience · 2024Article
- Prelimbic cortex inactivation prevents ABA renewal based on stress state.Behavioral neuroscience · 2023Article
- Prelimbic cortex inactivation prevents ABA renewal based on satiety state.Neurobiology of learning and memory · 2023Article
- Effects of alcohol and PARP inhibition on RNA ribosomal engagement in cortical excitatory neurons.Frontiers in molecular neuroscience · 2023Article
- EGR3 regulates opioid-related nociception and motivation in male rats.Psychopharmacology · 2022Article
- Optogenetic manipulation of the prelimbic cortex during fear memory reconsolidation alters fear extinction in a preclinical model of comorbid PTSD/AUD.Psychopharmacology · 2021Article
- New functions of the rodent prelimbic and infralimbic cortex in instrumental behavior.Neurobiology of learning and memory · 2021Review
- Sexually dimorphic prelimbic cortex mechanisms play a role in alcohol dependence: protection by endostatin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Sex-specific role for prefrontal cortical protein interacting with C kinase 1 in cue-induced cocaine seeking.Addiction biology · 2021Article
- Circuit selectivity in drug versus natural reward seeking behaviors.Journal of neurochemistry · 2021Review
- Chronic ethanol exposure differentially alters neuronal function in the medial prefrontal cortex and dentate gyrus.Neuropharmacology · 2021Article
- The role of the ventromedial prefrontal cortex and context in regulating fear learning and extinction.Psychology & neuroscience · 2020Article
- A persistent alcohol cue memory trace drives relapse to alcohol seeking after prolonged abstinence.Science advances · 2020Article
- Inactivation of the prelimbic cortex attenuates operant responding in both physical and behavioral contexts.Neurobiology of learning and memory · 2020Article
- Chronic Alcohol Exposure Induces Aberrant Mitochondrial Morphology and Inhibits Respiratory Capacity in the Medial Prefrontal Cortex of Mice.Frontiers in neuroscience · 2020Article
- Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats.Frontiers in behavioral neuroscience · 2020Article
- Glutamate receptor interacting protein acts within the prefrontal cortex to blunt cocaine seeking.Neuropharmacology · 2019Article
- Context-induced relapse after extinction versus punishment: similarities and differences.Psychopharmacology · 2019Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence indicates that drug relapse in humans is often provoked by exposure to the self-administered drug-associated context. An animal model called "ABA renewal procedure" has been used to study the context-induced relapse to drug seeking. Here, we reported a new and feasible training procedure for the ABA renewal method to explore the role of the prelimbic cortex in context-induced relapse to ethanol seeking. By using a saccharin fading technique, we trained rats to self-administer ethanol (10%). The drug delivery was paired with a discrete tone-light cue. Lever pressing was subsequently extinguished in a non-drug-associated context in the presence of the discrete cue. Rats were subsequently tested for reinstatement in contexts A or B, under extinction conditions. Ethanol-associated context induced the reinstatement of ethanol seeking and increased the expression of Fos in the prelimbic cortex. The rate of neural activation in the prelimbic cortex was 3.4% in the extinction context B and 7.7% in the drug-associated context A, as evidenced by double-labeling of Fos and the neuron-specific protein NeuN. The reversible inactivation of the neural activity in the prelimbic cortex with gamma-Aminobutyric acid (GABA) receptor agonists (muscimol + baclofen) attenuated the context-induced reinstatement of ethanol self-administration. These results demonstrated that the neuronal activation of the prelimbic cortex is involved in the context-induced reinstatement of ethanol seeking.
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