Evidence map›Paper›PMID 29089864›Full record

ReviewFrontiers in neuroscience2017

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms.

Andrew Kneynsberg, Benjamin Combs, Kyle Christensen, Gerardo Morfini, Nicholas M Kanaan

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Article
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  7. Review
  8. Article
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  10. Article
  11. Exploring Intrinsic Disorder in Human Synucleins and Associated Proteins.International journal of molecular sciences · 2024
    Article
  12. Tau-mediated synaptic dysfunction is coupled with HCN channelopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  13. Review
  14. Article
  15. Is Gulf War Illness a prolonged early phase tauopathy?Cytoskeleton (Hoboken, N.J.) · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Andrew KneynsbergNeuroscience Program, Michigan State University, East Lansing, MI, United States.
Benjamin CombsDepartment of Translational Science and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, United States.
Kyle ChristensenNeuroscience Program, Michigan State University, East Lansing, MI, United States.
Gerardo MorfiniDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Nicholas M KanaanNeuroscience Program, Michigan State University, East Lansing, MI, United States.
Michigan State University · USMercy Health Saint Mary's · USUniversity of Illinois Chicago · US

Funding

Tau Conformation in Tauopathies and Neuronal FunctionR01NS082730 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BRADY, SCOTT THOMAS, KANAAN, NICHOLAS M · 2014 to 2023
$7.0M
Tau-induced axonal degeneration in Alzheimer's disease and tauopathiesR01AG044372 · NIA · MICHIGAN STATE UNIVERSITY · PI KANAAN, NICHOLAS M · 2014 to 2018
$1.9M
Axonal Transport Deficits during Hereditary Spastic ParaplegiaR01NS066942 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MORFINI, GERARDO ANDRES · 2010 to 2014
$1.7M
Addressing the contribution of JNK3 to axonal pathology in Huntington's diseaseR21NS096642 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MORFINI, GERARDO ANDRES · 2016 to 2017
$430k
NIA NIH HHS R01 AG044372NINDS NIH HHS R01 NS066942NINDS NIH HHS R01 NS082730NINDS NIH HHS R21 NS096642
6 · The paper itself

Abstract

Tauopathies are a diverse group of diseases featuring progressive dying-back neurodegeneration of specific neuronal populations in association with accumulation of abnormal forms of the microtubule-associated protein tau. It is well-established that the clinical symptoms characteristic of tauopathies correlate with deficits in synaptic function and neuritic connectivity early in the course of disease, but mechanisms underlying these critical pathogenic events are not fully understood. Biochemical

Indexed as

Alzheimer's disease (AD)animal models of tauopathiesaxonal transportchronic traumatic encephalopathy (CTE)corticobasal degenerationneurodegenerationpick's diseaseprogressive supranuclear palsy

Identifiers

PMID29089864
PMCPMC5651019
OpenAlexW2763441547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.