Evidence map›Paper›PMID 29089858›Full record

ArticleCancer cell international2017

miR-1296-5p decreases ERBB2 expression to inhibit the cell proliferation in ERBB2-positive breast cancer.

Gang Chen, Mingfeng He, Yin Yin, Ting Yan, Wenfang Cheng, Zebo Huang, Lan Zhang, Huo Zhang, Ping Liu, Wei Zhu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer cell international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  12. Improved delivery of miR-1296 loaded cationic nanoliposomes for effective suppression of triple negative breast cancer.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021
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  19. Miniaturization of the Clonogenic Assay Using Confluence Measurement.International journal of molecular sciences · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Gang Chen *Department of Oncology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, 210029 People's Republic of China.
Mingfeng He *Department of Anesthesiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 People's Republic of China.
Yin Yin *Department of Gynecology and Obstetrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 China.
Ting YanSafety Assessment and Research Center for Drug, Pesticide and Veterinary Drug of Jiangsu Province, Nanjing Medical University, Nanjing, 211166 People's Republic of China.
Wenfang ChengDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 People's Republic of China.
Zebo HuangDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 People's Republic of China.
Lan ZhangDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 People's Republic of China.
Huo ZhangDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 People's Republic of China.
Ping LiuDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 People's Republic of China.
Wei ZhuDepartment of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 People's Republic of China.
Yichao ZhuDepartment of Physiology, Nanjing Medical University, Nanjing, 211166 People's Republic of China.
Nanjing Medical University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe tumor suppressive role of miR-1296 is observed in triple negative breast cancer (TNBC). However, the effect of miR-1296-5p in ERBB2-positive breast cancers remains obscure.

methodsWhether

resultsThe luciferase assay carrying ERBB2 3'-untranslated region-based reporters expressed in SK-BR-3 and BT-474 cells suggested that

conclusionsOur findings suggest that miR-1296-5p is involved in the regulation of proliferation in breast cancer cells via targeting ERBB2/mTORC1 signaling pathway.

Indexed as

Breast cancerERBB2miR-1296-5pmTORC1Proliferation

Identifiers

PMID29089858
PMCPMC5655974
OpenAlexW2765775696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.