Evidence map›Paper›PMID 29089755›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2017

Cost-effectiveness of the Aerobika* oscillating positive expiratory pressure device in the management of COPD exacerbations.

Shoghag Khoudigian-Sinani, Stacey Kowal, Jason A Suggett, Dominic P Coppolo

Registry-linked trialAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04540510 (Oscillatory Positive Expiratory Pressure Devices in Acute Inpatient Treatment of Pneumonia), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04540510 naterminatednot on this mapstarted 2019, after this paper: background citation

Oscillatory Positive Expiratory Pressure Devices in Acute Inpatient Treatment of Pneumonia

TypeinterventionalSponsorDanbury HospitalRan2019 to 2021Enrolled11ConditionsCommunity-acquired PneumoniaArmsOPEP therapy, Standard care
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Impact of AerobikaFrontiers in medicine · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shoghag Khoudigian-SinaniFaculty of Health Sciences, Department of Health Research, Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Stacey KowalQuintilesIMS, Seattle, WA, USA.
Jason A SuggettTrudell Medical International, London, ON, Canada.
Dominic P CoppoloMonaghan Medical Corporation, Syracuse, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCOPD places a huge clinical and economic burden on the US health care system, with acute exacerbations representing a key driver of direct medical costs. Current treatments, although effective in reducing symptoms and limiting exacerbations, do not adequately target the underlying disease processes that drive exacerbation development. The Aerobika* oscillating positive expiratory pressure (OPEP) device has been shown in a real-world effectiveness study to lower the frequency of moderate-to-severe exacerbations during a 30-day post-exacerbation period. This study sought to determine the impact on exacerbations and costs and to determine the cost-effectiveness of the Aerobika* device.

methodsData from published literature and national fee schedules were used to model the cost-effectiveness of the Aerobika* device in patients who had experienced an exacerbation in the previous month, or a post-exacerbation care population. Exacerbation trends and the impact of the Aerobika* device on reducing exacerbation frequency were modeled using a one-year Markov model with monthly cycles and three health states: (i) no exacerbation, (ii) exacerbation, and (iii) death. Scenario analysis and one-way sensitivity analysis (OWSA) were also performed.

resultsWhen the effect of Aerobika* device was assumed to last 30 days, use of the device resulted in cost-savings ($553 per patient) and improved outcomes (ie, six fewer exacerbations per 100 patients per year) compared to no OPEP/positive expiratory pressure therapy. When the effect of the Aerobika* device was assumed to extend beyond the conservative 30-day time frame, the Aerobika* device remained the dominant strategy (21 fewer exacerbations per 100 patients per year; cost savings of $1,952 per patient). Consistency in findings after performing OWSAs indicates the robustness of results.

conclusionThe Aerobika* device is a cost-effective treatment option that provides clinical benefit and results in direct medical cost savings in a post-exacerbation care COPD population.

Indexed as

Health Care CostsAdrenal Cortex HormonesAnti-Bacterial AgentsCost-Benefit AnalysisCost SavingsDisease ProgressionDrug CostsEmergency Service, HospitalEquipment DesignHospital CostsHumansLungMarkov ChainsModels, EconomicPatient AdmissionPositive-Pressure RespirationAdrenal Cortex HormonesAnti-Bacterial AgentsAerobika* deviceCOPDcost-effectivenessexacerbations

Identifiers

PMID29089755
PMCPMC5655131

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.