Evaluation of the sterility of single-dose medications used in a multiple-dose fashion.

Elizabeth P Martin, Jean Mukherjee, Claire R Sharp, Virginia B Sinnott-Stutzman

Abstract readEvaluation Study

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elizabeth P MartinCape Cod Veterinary Specialists, 11 Bourne Bridge Approach, Buzzards Bay, Massachusetts 02532, USA (Martin); Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Mukherjee); College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, 90 South Street, Murdoch, Western Australia 6150 (Sharp); Angell Animal Medical Center, 350 S Huntington Avenue, Boston, Massachusetts 02130, USA (Sinnott-Stutzman).

Jean MukherjeeCape Cod Veterinary Specialists, 11 Bourne Bridge Approach, Buzzards Bay, Massachusetts 02532, USA (Martin); Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Mukherjee); College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, 90 South Street, Murdoch, Western Australia 6150 (Sharp); Angell Animal Medical Center, 350 S Huntington Avenue, Boston, Massachusetts 02130, USA (Sinnott-Stutzman).

Claire R SharpCape Cod Veterinary Specialists, 11 Bourne Bridge Approach, Buzzards Bay, Massachusetts 02532, USA (Martin); Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Mukherjee); College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, 90 South Street, Murdoch, Western Australia 6150 (Sharp); Angell Animal Medical Center, 350 S Huntington Avenue, Boston, Massachusetts 02130, USA (Sinnott-Stutzman).

Virginia B Sinnott-StutzmanCape Cod Veterinary Specialists, 11 Bourne Bridge Approach, Buzzards Bay, Massachusetts 02532, USA (Martin); Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Mukherjee); College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, 90 South Street, Murdoch, Western Australia 6150 (Sharp); Angell Animal Medical Center, 350 S Huntington Avenue, Boston, Massachusetts 02130, USA (Sinnott-Stutzman).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial proliferation was evaluated in single-dose medications used in a multi-dose fashion and when medications were intentionally inoculated with bacteria. Of 5 experimentally punctured medications, 1 of 75 vials (50% dextrose) became contaminated. When intentionally inoculated, hydroxyethyl starch and heparinized saline supported microbial growth. Based on these findings, it is recommended that hydroxyethyl starch and heparinized saline not be used in a multi-dose fashion.

Indexed as

Dosage FormsDrug ContaminationVeterinary DrugsAnimalsDrug PackagingInfusions, ParenteralPseudomonas aeruginosaStaphylococcus aureusDosage FormsVeterinary Drugs

Identifiers

PMID29089656

PMCPMC5640284

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.