ArticleScientific reports2017
miR-16 and miR-103 impact 5-HT
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Global research states and trends of micro RNA in irritable bowel syndrome: a bibliometric analysis.Clinical and experimental medicine · 2024Pooled it
- Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.Nutrients · 2026Review
- Review
- Mesenchymal stem cell-derived apoptotic vesicles regulate irritable bowel syndrome in mice via the 5-HT brain-gut axis.Stem cell research & therapy · 2025Article
- Decoding Abdominal Pain in Constipation-predominant Irritable Bowel Syndrome and Functional Constipation: Mechanisms and Managements.Current gastroenterology reports · 2025Review
- Review
- Peripheral Serotonin Controls Dietary Fat Absorption and Chylomicron Secretion via 5-HT4 Receptor in Males.Endocrinology · 2024Article
- New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics.Journal of gastroenterology · 2023Review
- Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.Journal of translational medicine · 2023Article
- Functional Implications and Clinical Potential of MicroRNAs in Irritable Bowel Syndrome: A Concise Review.Digestive diseases and sciences · 2023Review
- Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies.Nature reviews. Gastroenterology & hepatology · 2022Review
- The Role of MicroRNA and Microbiota in Depression and Anxiety.Frontiers in behavioral neuroscience · 2022Review
- Article
- Role of microRNAs in Disorders of Gut-Brain Interactions: Clinical Insights and Therapeutic Alternatives.Journal of personalized medicine · 2021Review
- The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.Journal of cellular and molecular medicine · 2021Article
- Disorders of the enteric nervous system - a holistic view.Nature reviews. Gastroenterology & hepatology · 2021Review
- The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p, and MicroRNA-338-3p Are Downregulated in Irritable Bowel Syndrome and Are Associated With Barrier Function and MAPK Signaling.Gastroenterology · 2021Article
- The enteric nervous system in gastrointestinal disease etiology.Cellular and molecular life sciences : CMLS · 2021Review
- Micro-organic basis of functional gastrointestinal (GI) disorders: Role of microRNAs in GI pacemaking cells.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence.Pharmaceuticals (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 17 institutions in 6 countries.
Carolin WohlfarthDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Stefanie SchmitteckertDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Janina D HärtleDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Lesley A HoughtonUniversity of Leeds, St. James's University Hospital, LS97TF, Leeds, UK.
Harsh DweepMedical Research Centre, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, 68167, Germany.
Marina ForteaDigestive System Research Unit, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Facultat de Medicina), 08035, Barcelona, Spain.
Ghazaleh AssadiDepartment of Biosciences and Nutrition, Karolinska Institutet, 17177, Stockholm, Sweden.
Alexander BraunDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Tanja MedererDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Sarina PöhnerDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Philip P BeckerDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Christine FischerInstitute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Martin GranzowInstitute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Hubert MönnikesMartin-Luther-Hospital, 14193, Berlin-Grunewald, Germany.
Emeran A MayerOppenheimer Centre for Neurobiology of Stress, Division of Digestive Diseases, University of California, Los Angeles, CA 90095-7378, USA.
Gregory SayukWashington University School of Medicine, St. Louis, MO, 63110, USA.
Guy BoeckxstaensTARGID, University Hospital Leuven, 3000, Leuven, Belgium.
Mira M WoutersTARGID, University Hospital Leuven, 3000, Leuven, Belgium.
Magnus SimrénDepartment of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345, Gothenburg, Sweden.
Greger LindbergDepartment of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Huddinge, 17176, Stockholm, Sweden.
Bodil OhlssonDepartment of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, 22241, Lund, Sweden.
Peter Thelin SchmidtDepartment of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, 14186, Stockholm, Sweden.
Aldona DlugoszDepartment of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Huddinge, 17176, Stockholm, Sweden.
Lars AgreusDivision for Family Medicine and Primary Care, Karolinska Institutet, 14183, Huddinge, Sweden.
Anna AndreassonDepartment of Medicine, Solna, Karolinska Institutet, 171 76, Solna, Sweden.
Mauro D'AmatoUnit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, 171 76, Stockholm, Sweden.
Barbara BurwinkelMolecular Epidemiology Group, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Justo Lorenzo BermejoInstitute of Medical Biometry and Informatics, University of Heidelberg, 69120, Heidelberg, Germany.
Ralph RöthDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Felix LasitschkaInstitute of Pathology, University of Heidelberg, 69120, Heidelberg, Germany.
Maria VicarioDigestive System Research Unit, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Facultat de Medicina), 08035, Barcelona, Spain.
Marco MetzgerDepartment Tissue Engineering and Regenerative Medicine (TERM), University Hospital Wuerzburg, 97082, Wuerzburg, Germany.
Javier SantosDigestive System Research Unit, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Facultat de Medicina), 08035, Barcelona, Spain.
Gudrun A RappoldDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Cristina MartinezDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.
Beate NieslerDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany. beate.niesler@med.uni-heidelberg.de.
Heidelberg University · DEKarolinska Institutet · SEKarolinska University Hospital · SEKU Leuven · BEUniversitat Autònoma de Barcelona · ESGerman Cancer Research Center · DEMartin-Luther-Krankenhaus · DESkåne University Hospital · SEStockholm University · SEUniversitätsklinikum Würzburg · DEUniversity of California, Los Angeles · USUniversity of Gothenburg · SEUniversity of Leeds · GBVall d'Hebron Hospital Universitari · ESVall d'Hebron Institut de Recerca · ESWashington University in St. Louis · USZimmer Biomet (Germany) · DE
Funding
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2MNIDDK NIH HHS R01 DK048351
Abstract
Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT
Indexed as
DiarrheaDown-RegulationGene Expression RegulationGenetic Association StudiesHumansIrritable Bowel SyndromeJejunumMicroRNAsMutationPhenotypePolymorphism, Single NucleotideProtein BindingQuality of LifeReceptors, Serotonin, 5-HT4Signal TransductionWork PerformanceMicroRNAsMIRN103 microRNA, humanMIRN107 microRNA, humanMIRN16 microRNA, humanReceptors, Serotonin, 5-HT4
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.