ArticleScientific reports2017
Molecular Insights into Antimicrobial Resistance Traits of Multidrug Resistant Enteric Pathogens isolated from India.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
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- Investigating the molecular transmission dynamics ofJournal of bacteriology · 2025Article
- Antimicrobial resistance burden, and mechanisms of its emergence in gut microbiomes of Indian population.Frontiers in microbiomes · 2024Article
- A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital.Frontiers in microbiology · 2024Article
- Strategies to Overcome Antimicrobial Resistance in Nosocomial Infections, A Review and Update.Infectious disorders drug targets · 2024Review
- Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Potential influence of antimicrobial resistance gene content in probiotic bacteria on the gut resistome ecosystems.Frontiers in nutrition · 2023Review
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- Editorial: Antibiotic potentiators against drug-resistant pathogens: Discovery, development and clinical applications.Frontiers in microbiology · 2023Article
- Insights into Carbapenem Resistance inInternational journal of molecular sciences · 2022Review
- Mobility of antimicrobial resistance across serovars and disease presentations in non-typhoidalMicrobial genomics · 2022Article
- Impact of spent engine oil contamination on the antibiotic resistome of a tropical agricultural soil.Ecotoxicology (London, England) · 2021Article
- Environmental hotspots for antibiotic resistance genes.MicrobiologyOpen · 2021Review
- Galactose-Clicked Curcumin-Mediated Reversal of Meropenem Resistance amongAntibiotics (Basel, Switzerland) · 2021Article
- Foodborne Pathogenic Vibrios: Antimicrobial Resistance.Frontiers in microbiology · 2021Review
- Streptomyces sp SM01 isolated from Indian soil produces a novel antibiotic picolinamycin effective against multi drug resistant bacterial strains.Scientific reports · 2020Article
- Survey of drug resistance associated gene mutations in Mycobacterium tuberculosis, ESKAPE and other bacterial species.Scientific reports · 2020Article
- Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression.Frontiers in cell and developmental biology · 2020Review
- Genomic plasticity associated with antimicrobial resistance inProceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
20 authors at 5 institutions in 1 country.
Funding
Abstract
Emergence of antimicrobial resistant Gram-negative bacteria has created a serious global health crisis and threatens the effectiveness of most, if not all, antibiotics commonly used to prevent and treat bacterial infections. There is a dearth of detailed studies on the prevalence of antimicrobial resistance (AMR) patterns in India. Here, we have isolated and examined AMR patterns of 654 enteric pathogens and investigated complete genome sequences of isolates from six representative genera, which in aggregate encode resistance against 22 antibiotics representing nine distinct drug classes. This study revealed that ~97% isolates are resistant against ≥2 antibiotics, ~24% isolates are resistant against ≥10 antibiotics and ~3% isolates are resistant against ≥15 antibiotics. Analyses of whole genome sequences of six extensive drug resistant enteric pathogens revealed presence of multiple mobile genetic elements, which are physically linked with resistance traits. These elements are therefore appearing to be responsible for disseminating drug resistance among bacteria through horizontal gene transfer. The present study provides insights into the linkages between the resistance patterns to certain antibiotics and their usage in India. The findings would be useful to understand the genetics of resistance traits and severity of and difficulty in tackling AMR enteric pathogens.
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