ReviewNature reviews. Urology2017
Microfluidics for sperm analysis and selection.
Review in Nature reviews. Urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03960229 (The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor), which is not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor: a Randomized Controlled Trial
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 217 citations in OpenAlex.
- Pooled it
- Advanced Sperm Selection Strategies as a Treatment for Infertile Couples: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Ability and accuracy of the smartphone-based O`VIEW-M® sperm test: Useful tool in the era of Covid-19.PloS one · 2022Trial
- Microfluidic Intracytoplasmic Sperm Injection (MICSI): A Novel Platform for Sperm Isolation, Selection, and Injection Into Oocytes.Andrology · 2026Article
- A sperm racetrack to separate sperm by swim speed.Lab on a chip · 2026Article
- Evaluation of the Feasibility of a Microfluidic Method Using the ZYMŌT System for Canine Sperm Selection.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Separation of sperm based on rheotaxis mechanism using a microfluidic device.Clinical and experimental reproductive medicine · 2026Article
- From reservoir to rendezvous: the journey of sperm through the oviduct.Reproduction, fertility, and development · 2026Review
- Expert-Annotated Optical Microscopy Images of Human Sperm for Detection and DNA Fragmentation Assessment.Scientific data · 2025Article
- Elevated ApoB/ApoA ratio is associated with recurrent kidney stones in a Chinese adult population: a retrospective, propensity-matched analysis.European journal of medical research · 2025Article
- Simple and rapid microfluidic device for processing raw human semen and separation of motile sperm based on their intrinsic behavior and morphology.Scientific reports · 2025Article
- Straining Flow Effects on Sperm Flagellar Energetics in Microfluidic Cross-Slot Traps.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Current drawbacks and future perspectives in the diagnosis and treatment of male factor infertility, with a focus on FSH treatment: an expert opinion.Journal of endocrinological investigation · 2025Review
- Soil-mimicking microfluidic devices reveal restricted flagellar motility of Bradyrhizobium diazoefficiens under microconfinement.Communications biology · 2025Article
- Modeling diffusive search by non-adaptive sperm: Empirical and computational insights.PLoS computational biology · 2025Article
- Open-Channel Droplet Microfluidic Platform for Passive Generation of Human Sperm Microdroplets.ACS biomaterials science & engineering · 2025Article
- Sperm Separation and Selection Techniques to Mitigate Sperm DNA Damage.Life (Basel, Switzerland) · 2025Review
- Boar Sperm Motility Assessment Using Computer-Assisted Sperm Analysis: Current Practices, Limitations, and Methodological Challenges.Animals : an open access journal from MDPI · 2025Review
- Swarm Autonomy: From Agent Functionalization to Machine Intelligence.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Development of a low-cost microfluidic chip for hyaluronidase-free oocyte denudation in mammals.Biotechnology notes (Amsterdam, Netherlands) · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility is a growing global health issue with far-reaching socioeconomic implications. A downward trend in male fertility highlights the acute need for affordable and accessible diagnosis and treatment. Assisted reproductive technologies are effective in treating male infertility, but their success rate has plateaued at ∼33% per cycle. Many emerging opportunities exist for microfluidics - a mature technology in other biomedical areas - in male infertility diagnosis and treatment, and promising microfluidic approaches are under investigation for addressing male infertility. Microfluidic approaches can improve our fundamental understanding of sperm motion, and developments in microfluidic devices that use microfabrication and sperm behaviour can aid semen analysis and sperm selection. Many burgeoning possibilities exist for engineers, biologists, and clinicians to improve current practices for infertility diagnosis and treatment. The most promising avenues have the potential to improve medical practice, moving innovations from research laboratories to clinics and patients in the near future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.