ArticleNature communications2017
Homeostatic plasticity shapes the visual system's first synapse.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Divergent mechanisms of neural adaptation and instability in the mammalian retina.Current biology : CB · 2025Article
- Article
- Cellular and Molecular Mechanisms Regulating Retinal Synapse Development.Annual review of vision science · 2024Review
- A pupillary contrast response in mice and humans: Neural mechanisms and visual functions.Neuron · 2024Article
- Distributed feature representations of natural stimuli across parallel retinal pathways.Nature communications · 2024Article
- Cell numbers, cell ratios, and developmental plasticity in the rod pathway of the mouse retina.Journal of anatomy · 2023Review
- Neural and Müller glial adaptation of the retina to photoreceptor degeneration.Neural regeneration research · 2023Review
- AMIGO1 Promotes Axon Growth and Territory Matching in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Retinal Plasticity.International journal of molecular sciences · 2022Review
- Disassembly and rewiring of a mature converging excitatory circuit following injury.Cell reports · 2021Article
- Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration.iScience · 2021Article
- Coculture techniques for modeling retinal development and disease, and enabling regenerative medicine.Stem cells translational medicine · 2020Review
- A pathoconnectome of early neurodegeneration: Network changes in retinal degeneration.Experimental eye research · 2020Article
- Article
- Homeostatic Plasticity Shapes the Retinal Response to Photoreceptor Degeneration.Current biology : CB · 2020Article
- AMIGO2 Scales Dendrite Arbors in the Retina.Cell reports · 2019Article
- Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit.Cell reports · 2019Article
- Homeostatic plasticity in neural development.Neural development · 2018Review
- Article
- A Pixel-Encoder Retinal Ganglion Cell with Spatially Offset Excitatory and Inhibitory Receptive Fields.Cell reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Vision in dim light depends on synapses between rods and rod bipolar cells (RBCs). Here, we find that these synapses exist in multiple configurations, in which single release sites of rods are apposed by one to three postsynaptic densities (PSDs). Single RBCs often form multiple PSDs with one rod; and neighboring RBCs share ~13% of their inputs. Rod-RBC synapses develop while ~7% of RBCs undergo programmed cell death (PCD). Although PCD is common throughout the nervous system, its influences on circuit development and function are not well understood. We generate mice in which ~53 and ~93% of RBCs, respectively, are removed during development. In these mice, dendrites of the remaining RBCs expand in graded fashion independent of light-evoked input. As RBC dendrites expand, they form fewer multi-PSD contacts with rods. Electrophysiological recordings indicate that this homeostatic co-regulation of neurite and synapse development preserves retinal function in dim light.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.