ArticleScientific reports2017
Microgel assisted Lab-on-Fiber Optrode.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Article
- Innovative Photonic Sensors for Safety and Security, Part III: Environment, Agriculture and Soil Monitoring.Sensors (Basel, Switzerland) · 2023Review
- Innovative Photonic Sensors for Safety and Security, Part I: Fundamentals, Infrastructural and Ground Transportations.Sensors (Basel, Switzerland) · 2023Review
- Innovative Photonic Sensors for Safety and Security, Part II: Aerospace and Submarine Applications.Sensors (Basel, Switzerland) · 2023Review
- Advanced Lab-on-Fiber Optrodes Assisted by Oriented Antibody Immobilization Strategy.Biosensors · 2022Article
- Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders.Sensors (Basel, Switzerland) · 2022Review
- Plasmonic nanomaterials with responsive polymer hydrogels for sensing and actuation.Chemical Society reviews · 2022Review
- Design and Optimization of All-Dielectric Fluorescence Enhancing Metasurfaces: Towards Advanced Metasurface-Assisted Optrodes.Biosensors · 2022Article
- Fibre-Optic Surface Plasmon Resonance Biosensor for Monoclonal Antibody Titer Quantification.Biosensors · 2021Article
- Optical Fiber Delivered Ultrafast Plasmonic Optical Switch.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- A novel Lab-on-Fiber Radiation Dosimeter for Ultra-high Dose Monitoring.Scientific reports · 2018Article
- Surface Functionalization by Stimuli-Sensitive Microgels for Effective Enzyme Uptake and Rational Design of Biosensor Setups.Polymers · 2018Article
- Light-microgel interaction in resonant nanostructures.Scientific reports · 2018Article
- Optimization Strategies for Responsivity Control of Microgel Assisted Lab-On-Fiber Optrodes.Sensors (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precision medicine is continuously demanding for novel point of care systems, potentially exploitable also for in-vivo analysis. Biosensing probes based on Lab-On-Fiber Technology have been recently developed to meet these challenges. However, devices exploiting standard label-free approaches (based on ligand/target molecule interaction) suffer from low sensitivity in all cases where the detection of small molecules at low concentrations is needed. Here we report on a platform developed through the combination of Lab-On-Fiber probes with microgels, which are directly integrated onto the resonant plasmonic nanostructure realized on the fiber tip. In response to binding events, the microgel network concentrates the target molecule and amplifies the optical response, leading to remarkable sensitivity enhancement. Moreover, by acting on the microgel degrees of freedom such as concentration and operating temperature, it is possible to control the limit of detection, tune the working range as well as the response time of the probe. These unique characteristics pave the way for advanced label-free biosensing platforms, suitably reconfigurable depending on the specific application.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.