ArticleNature communications2017
Quantifying the benefit of a proteome reserve in fluctuating environments.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed.
- Global proteolysis during starvation governs proteome remodeling and a survival-regrowth trade-off in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bridging energy and proteome allocation models allows prediction of the resource cost of traits across environments.PLoS biology · 2026Article
- Coarse-grained resource allocation modeling for decoding and rewiring microbial metabolism.Trends in microbiology · 2026Review
- Environment-dependent epistasis shapes adaptation to fluctuating resources.bioRxiv : the preprint server for biology · 2026Article
- Protein overabundance is driven by growth robustness.Science advances · 2026Article
- Quantitative Coarse-Grained Modeling of Microbial Metabolism: Uncovering Growth Laws, Environmental Responses, and Host-Circuit Coupling.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The E. coli escape wave in response to external ZnBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Reinforcement learning for adaptive control of phenotypically heterogeneous bacterial populations.bioRxiv : the preprint server for biology · 2025Article
- Phenotypic heterogeneity in lag reflects an evolutionarily stable bet-hedging strategy.bioRxiv : the preprint server for biology · 2025Article
- Gene expression cycles drive non-exponential bacterial growth.Physical review research · 2025Article
- Cell Geometry Limits Bacterial Metabolic Efficiency.bioRxiv : the preprint server for biology · 2025Article
- Systematic modulation of bacterial resource allocation by perturbing RNA polymerase availability via synthetic transcriptional switches.Nucleic acids research · 2025Article
- Protein overabundance is driven by growth robustness.bioRxiv : the preprint server for biology · 2025Article
- A mismatch between slow protein synthesis and fast environmental fluctuations determines tradeoffs in bacterial proteome allocation strategies.bioRxiv : the preprint server for biology · 2025Article
- Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources.mSystems · 2025Article
- Gene Expression Depends on the Interplay Among Growth, Resource Biogenesis, and Nutrient Quality.ACS synthetic biology · 2025Article
- Article
- Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli.Nature communications · 2025Article
- Single-cell data reveal heterogeneity of investment in ribosomes across a bacterial population.Nature communications · 2025Article
- Salinity-driven niche differentiation within the aquatic Luna-1 subcluster.ISME communications · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The overexpression of proteins is a major burden for fast-growing bacteria. Paradoxically, recent characterization of the proteome of Escherichia coli found many proteins expressed in excess of what appears to be optimal for exponential growth. Here, we quantitatively investigate the possibility that this overexpression constitutes a strategic reserve kept by starving cells to quickly meet demand upon sudden improvement in growth conditions. For cells exposed to repeated famine-and-feast cycles, we derive a simple relation between the duration of feast and the allocation of the ribosomal protein reserve to maximize the overall gain in biomass during the feast.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.