ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Frontal Eye Field Inactivation Diminishes Superior Colliculus Activity, But Delayed Saccadic Accumulation Governs Reaction Time Increases.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 39 citations in OpenAlex.
- Focal control of non-invasive deep brain stimulation using multipolar temporal interference.Bioelectronic medicine · 2025Article
- Disrupted microsaccade responses in late-life depression.Scientific reports · 2025Article
- Dissociating the Contributions of Frontal Eye Field Activity to Spatial Working Memory and Motor Preparation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Developmental maturation of causal signaling hubs in voluntary control of saccades and their functional controllability.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Functional characterization of the fronto-parietal reaching and grasping network: reversible deactivation of M1 and areas 2, 5, and 7b in awake behaving monkeys.Journal of neurophysiology · 2022Article
- Frontal eye field inactivation alters the readout of superior colliculus activity for saccade generation in a task-dependent manner.Journal of computational neuroscience · 2021Article
- Adaptive control of movement deceleration during saccades.PLoS computational biology · 2021Article
- Proof of Concept of Novel Visuo-Spatial-Motor Fall Prevention Training for Old People.Geriatrics (Basel, Switzerland) · 2021Article
- Eye-Tracking Training Improves Inhibitory Control in Children with Attention-Deficit/Hyperactivity Disorder.Brain sciences · 2021Article
- Neural Substrates of the Drift-Diffusion Model in Brain Disorders.Frontiers in computational neuroscience · 2021Review
- Computerized Eye-Tracking Training Improves the Saccadic Eye Movements of Children with Attention-Deficit/Hyperactivity Disorder.Brain sciences · 2020Article
- Spatiotemporal transformations for gaze control.Physiological reports · 2020Review
- Impairment but not abolishment of express saccades after unilateral or bilateral inactivation of the frontal eye fields.Journal of neurophysiology · 2020Article
- Flexible, multifunctional neural probe with liquid metal enabled, ultra-large tunable stiffness for deep-brain chemical sensing and agent delivery.Biosensors & bioelectronics · 2019Article
- Sensorimotor transformation elicits systematic patterns of activity along the dorsoventral extent of the superior colliculus in the macaque monkey.Communications biology · 2019Article
- Saccade metrics reflect decision-making dynamics during urgent choices.Nature communications · 2018Article
- Motor selection dynamics in FEF explain the reaction time variance of saccades to single targets.eLife · 2018Article
- Onset Matters: How Collicular Activity Relates to Saccade Initiation during Cortical Cooling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Assessing the Functional Role of Frontal Eye Fields in Voluntary and Reflexive Saccades Using Continuous Theta Burst Stimulation.Frontiers in neuroscience · 2018Article
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4 authors at 4 institutions in 3 countries.
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Abstract
Stochastic accumulator models provide a comprehensive framework for how neural activity could produce behavior. Neural activity within the frontal eye fields (FEFs) and intermediate layers of the superior colliculus (iSC) support such models for saccade initiation by relating variations in saccade reaction time (SRT) to variations in such parameters as baseline, rate of accumulation of activity, and threshold. Here, by recording iSC activity during reversible cryogenic inactivation of the FEF in four male nonhuman primates, we causally tested which parameter(s) best explains concomitant increases in SRT. While FEF inactivation decreased all aspects of ipsilesional iSC activity, decreases in accumulation rate and threshold poorly predicted accompanying increases in SRT. Instead, SRT increases best correlated with delays in the onset of saccade-related accumulation. We conclude that FEF signals govern the onset of saccade-related accumulation within the iSC, and that the onset of accumulation is a relevant parameter for stochastic accumulation models of saccade initiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.