ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Transient Hypoxemia Chronically Disrupts Maturation of Preterm Fetal Ovine Subplate Neuron Arborization and Activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- Decreased amygdala volume in adults after premature birth.Scientific reports · 2021Trial
- The role of persistent inflammation in failed recovery after perinatal brain injury: is resolution the cure?Journal of neuroinflammation · 2026Review
- Diffuse neuroinflammation and immature neuron loss in fetal Rhesus macaques after short-term intrauterine infection.Journal of neuroinflammation · 2026Article
- Heterogeneous, temporally consistent, and plastic brain development after preterm birth.Nature communications · 2025Article
- Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- New insights into epileptic spasm generation and treatment from the TTX animal model.Epilepsia open · 2025Article
- Article
- Individualized cortical gyrification in neonates with congenital heart disease.Brain communications · 2024Article
- Altered gray-to-white matter tissue contrast in preterm-born adults.CNS neuroscience & therapeutics · 2023Article
- Indirect evidence for altered dopaminergic neurotransmission in very premature-born adults.Human brain mapping · 2023Article
- Asiatic acid increased locomotor and head width by inducing brain-derived neurotrophic factor in intrauterine hypoxia-exposed zebrafish.Open veterinary journal · 2023Article
- Sleep Problems in Preschoolers With Autism Spectrum Disorder Are Associated With Sensory Sensitivities and Thalamocortical Overconnectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Effect of Hypoxia-Ischemia on the Expression of Iron-Related Proteins in Neonatal Rat Brains.Neural plasticity · 2023Article
- Developmental Brain Injury and Social Determinants of Health: Opportunities to Combine Preclinical Models for Mechanistic Insights into Recovery.Developmental neuroscience · 2023Review
- A Simplified Paradigm of Late Gestation Transient Prenatal Hypoxia to Investigate Functional and Structural Outcomes from a Developmental Hypoxic Insult.Bio-protocol · 2022Article
- Efficient Claustrum Segmentation in T2-weighted Neonatal Brain MRI Using Transfer Learning from Adult Scans.Clinical neuroradiology · 2022Article
- In Utero MRI Identifies Impaired Second Trimester Subplate Growth in Fetuses with Congenital Heart Disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Neonatal Hypoxia-Ischemia Causes Persistent Intracortical Circuit Changes in Layer 4 of Rat Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Fetal origin of brain dysmaturation in congenital heart disease - Challenges and opportunities for interventions.Journal of neonatal-perinatal medicine · 2022Article
- Deficits in Seizure Threshold and Other Behaviors in Adult Mice without Gross Neuroanatomic Injury after Late Gestation Transient Prenatal Hypoxia.Developmental neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Preterm infants are at risk for a broad spectrum of neurobehavioral disabilities associated with diffuse disturbances in cortical growth and development. During brain development, subplate neurons (SPNs) are a largely transient population that serves a critical role to establish functional cortical circuits. By dynamically integrating into developing cortical circuits, they assist in consolidation of intracortical and extracortical circuits. Although SPNs reside in close proximity to cerebral white matter, which is particularly vulnerable to oxidative stress, the susceptibility of SPNs remains controversial. We determined SPN responses to two common insults to the preterm brain: hypoxia-ischemia and hypoxia. We used a preterm fetal sheep model using both sexes that reproduces the spectrum of human cerebral injury and abnormal cortical growth. Unlike oligodendrocyte progenitors, SPNs displayed pronounced resistance to early or delayed cell death from hypoxia or hypoxia-ischemia. We thus explored an alternative hypothesis that these insults alter the maturational trajectory of SPNs. We used DiOlistic labeling to visualize the dendrites of SPNs selectively labeled for complexin-3. SPNs displayed reduced basal dendritic arbor complexity that was accompanied by chronic disturbances in SPN excitability and synaptic activity. SPN dysmaturation was significantly associated with the level of fetal hypoxemia and metabolic stress. Hence, despite the resistance of SPNs to insults that trigger white matter injury, transient hypoxemia disrupted SPN arborization and functional maturation during a critical window in cortical development. Strategies directed at limiting the duration or severity of hypoxemia during brain development may mitigate disturbances in cerebral growth and maturation related to SPN dysmaturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.