Evidence map›Paper›PMID 29089383›Full record

ArticleThe Journal of biological chemistry2017

hERG1a and hERG1b potassium channel subunits directly interact and preferentially form heteromeric channels.

Beth A McNally, Zeus D Pendon, Matthew C Trudeau

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pairwise biosynthesis of ion channels stabilizes excitability and mitigates arrhythmias.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Mutation-Specific Differences in Kv7.1 (International journal of molecular sciences · 2022
    Review
  9. The ERG1 KFrontiers in molecular neuroscience · 2022
    Review
  10. Long QT SyndromeCirculation. Arrhythmia and electrophysiology · 2021
    Article
  11. Article
  12. Cardiac hERG KHandbook of experimental pharmacology · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. A stable cell line inducibly expressing hERG1a/1b heteromeric channels.Journal of pharmacological and toxicological methods
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Beth A McNallyFrom the Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
Zeus D PendonFrom the Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
Matthew C TrudeauFrom the Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201 mtrudeau@som.umaryland.edu.ORCID 0000-0002-6971-2589
University of Maryland, Baltimore · US

Funding

Molecular Physiology of HERG (KCNH2) Pottasium ChannelsR01HL083121 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TRUDEAU, MATTHEW C · 2009 to 2014
$1.9M
NHLBI NIH HHS R01 HL083121
6 · The paper itself

Abstract

Voltage-activated human ether-á-go-go-related gene (hERG) potassium channels are critical for the repolarization of cardiac action potentials and tune-spike frequency adaptation in neurons. Two isoforms of mammalian ERG1 channel subunits, ERG1a and ERG1b, are the principal subunits that conduct the I

Indexed as

ERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsFluorescence Resonance Energy TransferHeartHumansIon Channel GatingLong QT SyndromeMyocardiumPotassium Channels, Voltage-GatedProtein IsoformsProtein SubunitsERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsKCNH1 protein, humanPotassium Channels, Voltage-GatedProtein IsoformsProtein Subunitscysteine-mediated cross-linkingelectrophysiologyfluorescence resonance energy transfer (FRET)hERGhERG1ahERG1bhuman eag-related geneKCNH2Long QT syndromepotassium channel

Identifiers

PMID29089383
PMCPMC5766944
OpenAlexW2765598777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.