ArticleThe Journal of experimental medicine2017
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
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In one paragraph
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 4 pooled it
17.4field-weighted citation impact, top 1% of its field
What it found
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Who cites it
200 citing papers in PubMed, 4 syntheses or guidelines pooled it, 287 citations in OpenAlex.
- Population stratified differences between ATG16L1 rs2241880 polymorphism with Crohn's disease risk: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Role of Mitochondria in Inflammatory Bowel Diseases: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target.Nature reviews. Drug discovery · 2020Pooled it
- Systematic review: gastrointestinal infection and incident inflammatory bowel disease.Alimentary pharmacology & therapeutics · 2020Pooled it
- Polymeric alpha-1 antitrypsin perturbs Paneth cell proteostasis and exacerbates intestinal inflammation.Signal transduction and targeted therapy · 2026Article
- Avobenzone induces intestinal injury by targeting ATG14 and impairing mitophagy.Cell communication and signaling : CCS · 2026Article
- Biogenesis of TNF-α-insights into proteostasis and inflammation.The FEBS journal · 2026Review
- Crohn's Disease: From Immune Dysregulation to Intestinal Damage.Inflammation · 2026Review
- OTOP2 proton channel couples luminal pH sensing to intestinal immune homeostasis.The Journal of biological chemistry · 2026Article
- REDD1 deficiency alleviates podocyte PANoptosis and restores autophagy in diabetic kidney disease.Molecular medicine (Cambridge, Mass.) · 2026Article
- Circular RNAs in Intestinal Mucosal Homeostasis and Pathologies.Non-coding RNA · 2026Review
- A study on the mechanism of IGFBP-3 affecting autophagy to partially protect against inflammatory damage in inflammatory bowel disease.Journal of bioenergetics and biomembranes · 2026Article
- The c-Abl-RIPK3 Axis Drives Mitochondrial Dysfunction and Impaired Mitophagy in Gaucher Disease Models.Antioxidants (Basel, Switzerland) · 2026Article
- Type I and III interferons synergize with TNF to promote virally-triggered damage to the intestinal epithelium.bioRxiv : the preprint server for biology · 2026Article
- Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease.Seminars in immunopathology · 2026Review
- Targeting cell death in Crohn's disease: from mechanisms to medicines.Cell death discovery · 2026Review
- Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications.Molecular medicine (Cambridge, Mass.) · 2026Review
- Chronic enteritis triggered by diet westernization is driven by epithelial ATG16L1-mediated autophagy.Autophagy · 2026Article
- Aberrant methylation limits antitumoral inflammation in lung adenocarcinoma by restricting RIPK3 expression.Science advances · 2026Article
- Mitophagy in inflammatory bowel disease: regulatory mechanisms and therapeutic potential.Frontiers in cell and developmental biology · 2026Review
140 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Yu Matsuzawa-IshimotoKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY.
Yusuke ShonoDepartment of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID http://orcid.org/0000-0002-0459-1659
Luis E GomezKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY.
Vanessa M Hubbard-LuceyKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY.
Michael CammerMicroscopy Core, Office of Collaborative Science, New York University School of Medicine, New York, NY.ORCID http://orcid.org/0000-0003-4930-1739
Jessica NeilKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY.
M Zahidunnabi DewanHistopathology Core, Office of Collaborative Science, New York University School of Medicine, New York, NY.
Sophia R LiebermanDepartment of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID http://orcid.org/0000-0002-8112-4667
Amina LazrakDepartment of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.
Jill M MarinisPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA.
Allison BealPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA.ORCID http://orcid.org/0000-0001-5600-3380
Philip A HarrisPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA.ORCID http://orcid.org/0000-0002-5189-3326
John BertinPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA.
Chen LiuDepartments of Pathology and Laboratory Medicine, New Jersey Medical School and Robert Wood Johnson Medical School, Rutgers University, Newark, NJ.
Yi DingDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.
Marcel R M van den BrinkDepartment of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY vandenbm@mskcc.org.ORCID http://orcid.org/0000-0003-0696-4401
Ken CadwellKimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY ken.cadwell@med.nyu.edu.ORCID http://orcid.org/0000-0002-5860-0661
New York University · USGlaxoSmithKline (United States) · USMemorial Sloan Kettering Cancer Center · USRutgers, The State University of New Jersey · USUniversity of Rochester Medical Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MDiabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3MStrategies to enhance immune reconstitution after bone marrow transplantR01HL069929 · NHLBI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI VAN DEN BRINK, MARCEL R M · 2002 to 2015
$7.0MRedefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6MThe role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2MStrategies to Enhance Lymphoid Recovery After Radiation-Induced InjuryR01AI080455 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI VAN DEN BRINK, MARCEL R M · 2008 to 2012
$2.6MIL-22 in Thymic RegenerationR01AI101406 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI VAN DEN BRINK, MARCEL R M · 2012 to 2016
$2.5MMucosal Immunity and Microbiota in Intestinal Graft-versus-Host DiseaseR01AI100288 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI VAN DEN BRINK, MARCEL R M · 2012 to 2016
$2.2MRole of Nod2 in preventing intestinal disease downstream of microbial imbalancesR01DK103788 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, LOKE, PNG · 2015 to 2017
$1.3MInverted two photon laser scanning microscope for host defenseS10RR023704 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2008 to 2008
$500kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016087NCRR NIH HHS S10 RR023704NHLBI NIH HHS R01 HL069929NHLBI NIH HHS R01 HL123340NIAID NIH HHS R01 AI080455NIAID NIH HHS R01 AI100288NIAID NIH HHS R01 AI101406NIAID NIH HHS R01 AI121244NIDDK NIH HHS R01 DK093668NIDDK NIH HHS R01 DK103788
Abstract
A variant of the autophagy gene
Indexed as
ApoptosisAutophagyAnimalsAutophagy-Related ProteinsCaliciviridae InfectionsCarrier ProteinsCell SurvivalCytoprotectionEpithelial CellsGene DeletionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHomeostasisIntestinal MucosaMiceMice, Inbred C57BLAtg16l1 protein, mouseAutophagy-Related ProteinsCarrier ProteinsReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseTumor Necrosis Factor-alpha
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LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.