Evidence map›Paper›PMID 29089357›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Effects of Co-occurring Genomic Alterations on Outcomes in Patients with

Kathryn C Arbour, Emmett Jordan, Hyunjae Ryan Kim, Jordan Dienstag, Helena A Yu, Francisco Sanchez-Vega, Piro Lito, Michael Berger, David B Solit, Matthew Hellmann and 6 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 298 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
298citing papers in PubMed, 2 pooled it
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

298 citing papers in PubMed, 2 syntheses or guidelines pooled it, 447 citations in OpenAlex.

  1. KRAS G12C inhibitors in KRASFrontiers in immunology · 2026
    Pooled it
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  8. LncRNANAR cancer · 2026
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238 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Kathryn C ArbourDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Emmett JordanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Hyunjae Ryan KimDepartment of Pathology, Molecular Diagnostics Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Jordan DienstagDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Helena A YuDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Francisco Sanchez-VegaHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Piro LitoDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Michael BergerHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
David B SolitDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Matthew HellmannDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Mark G KrisDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Charles M RudinDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Ai NiDepartment of Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Maria ArcilaDepartment of Pathology, Molecular Diagnostics Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Marc LadanyiHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Gregory J RielyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. rielyg@mskcc.org.
Cornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
The Role of Focal Oncogene Amplifications in Lung CancerP01CA129243 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Piro Lito · 2007 to 2026
$31.2M
Dissecting KRAS oncoprotein signaling with small molecule inhibitorsR01CA230745 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Piro Lito · 2018 to 2026
$3.8M
Studies on the effects of a novel intermittent therapy on intratumoral clonal architecture and resistanceR01CA230267 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LITO, PIRO · 2019 to 2023
$2.0M
NCI NIH HHS P01 CA129243NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA230267NCI NIH HHS R01 CA230745
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomarkers, TumorMutationCarcinoma, Non-Small-Cell LungCombined Modality TherapyFemaleGenotypeHumansLung NeoplasmsMaleNeoplasm MetastasisNeoplasm StagingPrognosisProto-Oncogene Proteins p21(ras)Treatment OutcomeBiomarkers, TumorKRAS protein, humanProto-Oncogene Proteins p21(ras)

Identifiers

PMID29089357
PMCPMC5771996
OpenAlexW2767162493

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.