Evidence map›Paper›PMID 29089344›Full record

Trial reportJournal of the American Heart Association2017

Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial.

Abhinav Sharma, Nishant K Sekaran, Adrian Coles, Neha J Pagidipati, Udo Hoffmann, Daniel B Mark, Kerry L Lee, Hussein R Al-Khalidi, Michael T Lu, Patricia A Pellikka and 2 more

Erratum issued Registry-linked trialOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01174550 (PROspective Multicenter Imaging Study for Evaluation of Chest Pain - The PROMISE Trial), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01174550 nacompletednot on this map

PROspective Multicenter Imaging Study for Evaluation of Chest Pain - The PROMISE Trial

TypeinterventionalSponsorDuke UniversityRan2010 to 2014Enrolled10,003ConditionsChest PainArmsCoronary Angiography, Stress Echocardiogram, Nuclear Stress Test, Exercise Electrocardiogram
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Abhinav SharmaDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Nishant K SekaranDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Adrian ColesDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Neha J PagidipatiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Udo HoffmannMassachusetts General Hospital, Harvard Medical School, Boston, MA.
Daniel B MarkDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Kerry L LeeDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Hussein R Al-KhalidiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Michael T LuMassachusetts General Hospital, Harvard Medical School, Boston, MA.
Patricia A PellikkaMayo Clinic, Rochester, MN.
Quynh A TruongNew York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY.
Pamela S DouglasDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC pamela.douglas@duke.edu.
Clinical Research Institute · USDuke University · USHarvard University · USMassachusetts General Hospital · USMayo Clinic in Arizona · USNewYork–Presbyterian Hospital · USUniversity of Alberta · CA

Funding

PROMISE Trial: Clinical Coordinating CenterR01HL098237 · NHLBI · DUKE UNIVERSITY · PI DOUGLAS, PAMELA SUSAN · 2009 to 2014
$27.3M
PROMISE Trial: SDCCR01HL098236 · NHLBI · DUKE UNIVERSITY · PI LEE, KERRY L · 2009 to 2014
$5.0M
PROMISE Trial: Dx CoreR01HL098305 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2009 to 2014
$3.5M
PROMISE Trial: EQOL Coordinating CenterR01HL098235 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2009 to 2014
$1.6M
NHLBI NIH HHS R01 HL098235NHLBI NIH HHS R01 HL098236NHLBI NIH HHS R01 HL098237NHLBI NIH HHS R01 HL098305
6 · The paper itself

Abstract

backgroundThe impact of diabetes mellitus on the clinical presentation and noninvasive test (NIT) results among stable outpatients presenting with symptoms suggestive of coronary artery disease (CAD) has not been well described. METHODS AND

resultsThe PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) trial enrolled 10 003 patients with known diabetic status, of whom 8966 were tested as randomized and had interpretable NIT results (1908 with diabetes mellitus, 21%). Differences in symptoms and NIT results were evaluated using logistic regression. Patients with diabetes mellitus (versus without) were similar in age (median 61 versus 60 years) and sex (female 54% versus 52%), had a greater burden of cardiovascular comorbidities, and had a similar likelihood of nonchest pain symptoms (29% versus 27%). The Diamond-Forrester/Coronary Artery Surgery Study score predicted that patients with diabetes mellitus (versus without) had similar likelihood of obstructive CAD (low 1.8% versus 2.7%; intermediate 92.3% versus 92.6%; high 5.9% versus 4.7%). Physicians estimated patients with diabetes mellitus to have a higher likelihood of obstructive CAD (low to very low: 28.3% versus 40.1%; intermediate 63.9% versus 55.9%; high to very high 7.8% versus 4.0%). Patients with diabetes mellitus (versus without) were more likely to have a positive NIT result (15% versus 11%; adjusted odds ratio, 1.23;

conclusionsStable chest pain patients with and without diabetes mellitus have similar presentation and pretest likelihood of obstructive CAD; however, physicians perceive that patients with diabetes mellitus have a higher pretest likelihood of obstructive CAD, an assessment supported by increased risk of a positive NIT. Further evaluation of diabetes mellitus's influence on CAD assessment is required. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01174550.

Indexed as

Cardiac Imaging TechniquesAgedAngina PectorisComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseDiabetes MellitusEchocardiography, StressFemaleHumansLogistic ModelsMaleMiddle AgedMultidetector Computed TomographyNorth AmericaOdds Ratiocoronary artery diseasediabetes mellitusnoninvasive imaging

Identifiers

PMID29089344
PMCPMC5721780
OpenAlexW2766364055

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.