Evidence map›Paper›PMID 29089160›Full record

ReviewTrends in biochemical sciences2017

The Unsolved Problem of How Cells Sense Micron-Scale Curvature.

Kevin S Cannon, Benjamin L Woods, Amy S Gladfelter

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  4. Article
  5. Septin complexes: Ahead of the curve.Cytoskeleton (Hoboken, N.J.) · 2025
    Article
  6. Principles and regulation of mechanosensing.Journal of cell science · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Sensing the shape of a cell with reaction diffusion and energy minimization.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. The plasma membrane as a mechanochemical transducer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Review
  16. Motile curved bacteria are Pareto-optimal.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin S CannonDepartment of Biology, University of North Carolina at Chapel Hill, NC, USA.
Benjamin L WoodsDepartment of Biology, University of North Carolina at Chapel Hill, NC, USA.
Amy S GladfelterDepartment of Biology, University of North Carolina at Chapel Hill, NC, USA. Electronic address: amyglad@unc.edu.

Funding

Cytoplasmic Organization by phase transitionsR01GM081506 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GLADFELTER, AMY S · 2010 to 2023
$4.0M
NIGMS NIH HHS R01 GM081506
6 · The paper itself

Abstract

Membrane curvature is a fundamental feature of cells and their organelles. Much of what we know about how cells sense curved surfaces comes from studies examining nanometer-sized molecules on nanometer-scale curvatures. We are only just beginning to understand how cells recognize curved topologies at the micron scale. In this review, we provide the reader with an overview of our current understanding of how cells sense and respond to micron-scale membrane curvature.

Indexed as

AnimalsCell MembraneEukaryotic CellsHumansIntracellular MembranesOrganellesBAR domainmembrane curvatureseptinSpoVM

Identifiers

PMID29089160
PMCPMC5705049

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.