Evidence map›Paper›PMID 29089042›Full record

ArticleBMC biology2017

Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.

Christopher J Stefan, William S Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M Valm, Jennifer Lippincott-Schwartz, Tim P Levine and 10 more

Abstract read
In one paragraph

Article in BMC biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Directing the Mobility of Guest Molecules in Nanoporous Materials by Linearly Polarized Light.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Review
  8. Article
  9. Overexpression ofPlant signaling & behavior · 2025
    Article
  10. Article
  11. Deciphering the determinants of recombinant protein expression across the human secretome.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Pathogen-induced rerouting of host membrane trafficking.Current opinion in cell biology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Reconstitution of ORP-mediated lipid exchange coupled to PI4P metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Christopher J StefanMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK. c.stefan@ucl.ac.uk.
William S TrimbleCell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Canada. wtrimble@sickkids.ca.
Sergio GrinsteinCell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Canada. sergio.grinstein@sickkids.ca.
Guillaume DrinUniversité Côte d'Azur, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France. drin@ipmc.cnrs.fr.
Karin ReinischDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, 06520, USA. karin.reinisch@yale.edu.
Pietro De CamilliDepartment of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Kavli Institute for Neuroscience and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT, 06510, USA. pietro.decamilli@yale.edu.
Sarah CohenNICHD, NIH, Bethesda, MD, USA.
Alex M ValmNICHD, NIH, Bethesda, MD, USA.
Jennifer Lippincott-SchwartzHHMI Janelia Research Campus, Ashburn, VA, USA. lippincottschwartzj@janelia.hhmi.org.
Tim P LevineUCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. tim.levine@ucl.ac.uk.
David B IaeaGenentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
Frederick R MaxfieldDepartment of Biochemistry, Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA. frmaxfie@med.cornell.edu.
Clare E FutterUCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. c.futter@ucl.ac.uk.
Emily R EdenUCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. e.eden@ucl.ac.uk.
Delphine JudithMolecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK.
Alexander R van VlietMolecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK.
Patrizia AgostinisLaboratory of Cell Death Research and Therapy, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Sharon A ToozeMolecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, London, UK. sharon.tooze@crick.ac.uk.
Ayumu SugiuraKobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Heidi M McBrideMontreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, H3A 2B4, Canada. heidi.mcbride@mcgill.ca.

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1M
MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLINGR01NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 1997 to 2021
$4.7M
Intracellular Cholesterol TransportR01GM123462 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MAXFIELD, FREDERICK R. · 2018 to 2021
$1.4M
Biotechnology and Biological Sciences Research Council BB/P003818/1Cancer Research UK FC001187Howard Hughes Medical InstituteMedical Research Council FC001187Medical Research Council G0801878Medical Research Council M010767Medical Research Council MC_UU_00012/6Medical Research Council MC_UU_12018/6Medical Research Council MR/M010767/1Medical Research Council P0010091NIDA NIH HHS P30 DA018343NIGMS NIH HHS R01 GM123462NINDS NIH HHS R01 NS036251Wellcome Trust FC001187
6 · The paper itself

Abstract

Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.

Indexed as

Cell CycleLipid MetabolismOrganelle BiogenesisBiological TransportCell Membrane

Identifiers

PMID29089042
PMCPMC5663033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.